Synthesis of biolabile thioalkyl-protected phosphates from an easily accessible phosphotriester precursor

Robust methods for the synthesis of mixed phosphotriesters are essential to accelerate the development of novel phosphate-containing bioactive molecules. To enable efficient cellular uptake, phosphate groups are commonly masked with biolabile protecting groups, such as S-acyl-2-thioethyl (SATE) este...

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Detalles Bibliográficos
Autores principales: Murphy, Lloyd D., Huxley, Kathryn E., Wilding, Ava, Robinson, Cyane, Foucart, Quentin P. O., Willems, Lianne I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189884/
https://www.ncbi.nlm.nih.gov/pubmed/37206382
http://dx.doi.org/10.1039/d3sc00693j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189884/
https://www.ncbi.nlm.nih.gov/pubmed/37206382
http://dx.doi.org/10.1039/d3sc00693j

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