Cargando…
Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1
We analyzed single nucleotide polymorphisms (SNPs) in PKNOX1 (rs2839629) and in the intergenic region between PKNOX1 and CBS (rs915854) by Sanger sequencing in 88 patients with multiple myeloma treated with bortezomib. All patients (n = 13) harboring a homozygous mutation in PKNOX1 (rs2839629) also...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189922/ https://www.ncbi.nlm.nih.gov/pubmed/37194045 http://dx.doi.org/10.1186/s40364-023-00490-9 |
| _version_ | 1785043185361223680 |
|---|---|
| author | Zhou, Xiang Han, Seungbin Cebulla, Nadine Haertle, Larissa Steinhardt, Maximilian J. Schirmer, Daniel Runau, Eva Flamm, Leon Terhorst, Calvin Jähnel, Laura Vogt, Cornelia Nerreter, Silvia Teufel, Eva Stanojkovska, Emilia Mersi, Julia Munawar, Umair Schindehütte, Magnus Blum, Robert Reinhold, Ann-Kristin Scherf-Clavel, Oliver Rittner, Heike L. Pham, Mirko Rasche, Leo Einsele, Hermann Sommer, Claudia Kortüm, K. Martin |
| author_facet | Zhou, Xiang Han, Seungbin Cebulla, Nadine Haertle, Larissa Steinhardt, Maximilian J. Schirmer, Daniel Runau, Eva Flamm, Leon Terhorst, Calvin Jähnel, Laura Vogt, Cornelia Nerreter, Silvia Teufel, Eva Stanojkovska, Emilia Mersi, Julia Munawar, Umair Schindehütte, Magnus Blum, Robert Reinhold, Ann-Kristin Scherf-Clavel, Oliver Rittner, Heike L. Pham, Mirko Rasche, Leo Einsele, Hermann Sommer, Claudia Kortüm, K. Martin |
| author_sort | Zhou, Xiang |
| collection | PubMed |
| description | We analyzed single nucleotide polymorphisms (SNPs) in PKNOX1 (rs2839629) and in the intergenic region between PKNOX1 and CBS (rs915854) by Sanger sequencing in 88 patients with multiple myeloma treated with bortezomib. All patients (n = 13) harboring a homozygous mutation in PKNOX1 (rs2839629) also had a homozygous mutated rs915854 genotype. Homozygous mutated genotypes of rs2839629 and rs915854 were significantly enriched in patients with painful peripheral neuropathy (PNP) (P < 0.0001), and homozygous mutated rs2839629 genotype was significantly enriched in patients with pain compared to patients with no pain (P = 0.04). In summary, both SNPs rs2839629 and/or rs915854 may be potential biomarkers predicting an increased risk to develop painful PNP under bortezomib. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40364-023-00490-9. |
| format | Online Article Text |
| id | pubmed-10189922 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-101899222023-05-18 Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1 Zhou, Xiang Han, Seungbin Cebulla, Nadine Haertle, Larissa Steinhardt, Maximilian J. Schirmer, Daniel Runau, Eva Flamm, Leon Terhorst, Calvin Jähnel, Laura Vogt, Cornelia Nerreter, Silvia Teufel, Eva Stanojkovska, Emilia Mersi, Julia Munawar, Umair Schindehütte, Magnus Blum, Robert Reinhold, Ann-Kristin Scherf-Clavel, Oliver Rittner, Heike L. Pham, Mirko Rasche, Leo Einsele, Hermann Sommer, Claudia Kortüm, K. Martin Biomark Res Correspondence We analyzed single nucleotide polymorphisms (SNPs) in PKNOX1 (rs2839629) and in the intergenic region between PKNOX1 and CBS (rs915854) by Sanger sequencing in 88 patients with multiple myeloma treated with bortezomib. All patients (n = 13) harboring a homozygous mutation in PKNOX1 (rs2839629) also had a homozygous mutated rs915854 genotype. Homozygous mutated genotypes of rs2839629 and rs915854 were significantly enriched in patients with painful peripheral neuropathy (PNP) (P < 0.0001), and homozygous mutated rs2839629 genotype was significantly enriched in patients with pain compared to patients with no pain (P = 0.04). In summary, both SNPs rs2839629 and/or rs915854 may be potential biomarkers predicting an increased risk to develop painful PNP under bortezomib. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40364-023-00490-9. BioMed Central 2023-05-16 /pmc/articles/PMC10189922/ /pubmed/37194045 http://dx.doi.org/10.1186/s40364-023-00490-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
| spellingShingle | Correspondence Zhou, Xiang Han, Seungbin Cebulla, Nadine Haertle, Larissa Steinhardt, Maximilian J. Schirmer, Daniel Runau, Eva Flamm, Leon Terhorst, Calvin Jähnel, Laura Vogt, Cornelia Nerreter, Silvia Teufel, Eva Stanojkovska, Emilia Mersi, Julia Munawar, Umair Schindehütte, Magnus Blum, Robert Reinhold, Ann-Kristin Scherf-Clavel, Oliver Rittner, Heike L. Pham, Mirko Rasche, Leo Einsele, Hermann Sommer, Claudia Kortüm, K. Martin Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1 |
| title | Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1 |
| title_full | Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1 |
| title_fullStr | Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1 |
| title_full_unstemmed | Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1 |
| title_short | Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1 |
| title_sort | bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in pknox1 |
| topic | Correspondence |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189922/ https://www.ncbi.nlm.nih.gov/pubmed/37194045 http://dx.doi.org/10.1186/s40364-023-00490-9 |
| work_keys_str_mv | AT zhouxiang bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT hanseungbin bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT cebullanadine bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT haertlelarissa bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT steinhardtmaximilianj bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT schirmerdaniel bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT runaueva bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT flammleon bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT terhorstcalvin bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT jahnellaura bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT vogtcornelia bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT nerretersilvia bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT teufeleva bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT stanojkovskaemilia bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT mersijulia bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT munawarumair bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT schindehuttemagnus bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT blumrobert bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT reinholdannkristin bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT scherfclaveloliver bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT rittnerheikel bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT phammirko bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT rascheleo bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT einselehermann bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT sommerclaudia bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 AT kortumkmartin bortezomibinducedperipheralneuropathyandsinglenucleotidepolymorphismsinpknox1 |