Antiviral Properties of HIV-1 Capsid Inhibitor GSK878

GSK878 is a newly described HIV-1 inhibitor that binds to the mature capsid (CA) hexamer in a pocket originally identified as the binding site of the well-studied CA inhibitor PF-74. Here, we show that GSK878 is highly potent, inhibiting an HIV-1 reporter virus in MT-2 cells with a mean 50% effectiv...

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Detalles Bibliográficos
Autores principales: Wang, Chunfu, Huang, Haichang, Mallon, Kirsten, Valera, Lourdes, Parcella, Kyle, Cockett, Mark I., Kadow, John F., Gillis, Eric P., Krystal, Mark, Fridell, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10190262/
https://www.ncbi.nlm.nih.gov/pubmed/37039636
http://dx.doi.org/10.1128/aac.01694-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10190262/
https://www.ncbi.nlm.nih.gov/pubmed/37039636
http://dx.doi.org/10.1128/aac.01694-22

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