Efficacy of Intravenously Administered Gepotidacin in Cynomolgus Macaques following a Francisella tularensis Inhalational Challenge

Francisella tularensis (F. tularensis) is a Centers for Disease Control (CDC) category “A” Gram-negative biothreat pathogen. Inhalation of F. tularensis can cause pneumonia and respiratory failure and is associated with high mortality rates without early treatment. Gepotidacin is a novel, first-in-c...

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Detalles Bibliográficos
Autores principales: Jakielaszek, Charles, Hilliard, Jamese J., Mannino, Frank, Hossain, Mohammad, Qian, Lian, Fishman, Cindy, Chou, Ying-Liang, Henning, Lisa, Novak, Joseph, Demons, Samandra, Hershfield, Jeremy, O’Dwyer, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10190672/
https://www.ncbi.nlm.nih.gov/pubmed/37097147
http://dx.doi.org/10.1128/aac.01381-22

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