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Mobile mechanical signal generator for macrophage polarization
The importance of mechanical signals in regulating the fate of macrophages is gaining increased attention recently. However, the recently used mechanical signals normally rely on the physical characteristics of matrix with non‐specificity and instability or mechanical loading devices with uncontroll...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10190931/ https://www.ncbi.nlm.nih.gov/pubmed/37324036 http://dx.doi.org/10.1002/EXP.20220147 |
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author | Jiang, Jiamiao Wang, Fei Huang, Weichang Sun, Jia Ye, Yicheng Ou, Juanfeng Liu, Meihuan Gao, Junbin Wang, Shuanghu Fu, Dongmei Chen, Bin Liu, Lu Peng, Fei Tu, Yingfeng |
author_facet | Jiang, Jiamiao Wang, Fei Huang, Weichang Sun, Jia Ye, Yicheng Ou, Juanfeng Liu, Meihuan Gao, Junbin Wang, Shuanghu Fu, Dongmei Chen, Bin Liu, Lu Peng, Fei Tu, Yingfeng |
author_sort | Jiang, Jiamiao |
collection | PubMed |
description | The importance of mechanical signals in regulating the fate of macrophages is gaining increased attention recently. However, the recently used mechanical signals normally rely on the physical characteristics of matrix with non‐specificity and instability or mechanical loading devices with uncontrollability and complexity. Herein, we demonstrate the successful fabrication of self‐assembled microrobots (SMRs) based on magnetic nanoparticles as local mechanical signal generators for precise macrophage polarization. Under a rotating magnetic field (RMF), the propulsion of SMRs occurs due to the elastic deformation via magnetic force and hydrodynamics. SMRs perform wireless navigation toward the targeted macrophage in a controllable manner and subsequently rotate around the cell for mechanical signal generation. Macrophages are eventually polarized from M0 to anti‐inflammatory related M2 phenotypes by blocking the Piezo1‐activating protein‐1 (AP‐1)‐CCL2 signaling pathway. The as‐developed microrobot system provides a new platform of mechanical signal loading for macrophage polarization, which holds great potential for precise regulation of cell fate.‐ |
format | Online Article Text |
id | pubmed-10190931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101909312023-06-14 Mobile mechanical signal generator for macrophage polarization Jiang, Jiamiao Wang, Fei Huang, Weichang Sun, Jia Ye, Yicheng Ou, Juanfeng Liu, Meihuan Gao, Junbin Wang, Shuanghu Fu, Dongmei Chen, Bin Liu, Lu Peng, Fei Tu, Yingfeng Exploration (Beijing) Research Article The importance of mechanical signals in regulating the fate of macrophages is gaining increased attention recently. However, the recently used mechanical signals normally rely on the physical characteristics of matrix with non‐specificity and instability or mechanical loading devices with uncontrollability and complexity. Herein, we demonstrate the successful fabrication of self‐assembled microrobots (SMRs) based on magnetic nanoparticles as local mechanical signal generators for precise macrophage polarization. Under a rotating magnetic field (RMF), the propulsion of SMRs occurs due to the elastic deformation via magnetic force and hydrodynamics. SMRs perform wireless navigation toward the targeted macrophage in a controllable manner and subsequently rotate around the cell for mechanical signal generation. Macrophages are eventually polarized from M0 to anti‐inflammatory related M2 phenotypes by blocking the Piezo1‐activating protein‐1 (AP‐1)‐CCL2 signaling pathway. The as‐developed microrobot system provides a new platform of mechanical signal loading for macrophage polarization, which holds great potential for precise regulation of cell fate.‐ John Wiley and Sons Inc. 2023-04-03 /pmc/articles/PMC10190931/ /pubmed/37324036 http://dx.doi.org/10.1002/EXP.20220147 Text en © 2023 The Authors. Exploration published by Henan University and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Jiang, Jiamiao Wang, Fei Huang, Weichang Sun, Jia Ye, Yicheng Ou, Juanfeng Liu, Meihuan Gao, Junbin Wang, Shuanghu Fu, Dongmei Chen, Bin Liu, Lu Peng, Fei Tu, Yingfeng Mobile mechanical signal generator for macrophage polarization |
title | Mobile mechanical signal generator for macrophage polarization |
title_full | Mobile mechanical signal generator for macrophage polarization |
title_fullStr | Mobile mechanical signal generator for macrophage polarization |
title_full_unstemmed | Mobile mechanical signal generator for macrophage polarization |
title_short | Mobile mechanical signal generator for macrophage polarization |
title_sort | mobile mechanical signal generator for macrophage polarization |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10190931/ https://www.ncbi.nlm.nih.gov/pubmed/37324036 http://dx.doi.org/10.1002/EXP.20220147 |
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