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The multiple roles of salt-inducible kinases in regulating physiology

Salt-inducible kinases (SIKs), which comprise a family of three homologous serine-threonine kinases, were first described for their role in sodium sensing but have since been shown to regulate multiple aspects of physiology. These kinases are activated or deactivated in response to extracellular sig...

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Autores principales: Jagannath, Aarti, Taylor, Lewis, Ru, Yining, Wakaf, Zeinab, Akpobaro, Kayomavua, Vasudevan, Sridhar, Foster, Russell G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10190946/
https://www.ncbi.nlm.nih.gov/pubmed/36731029
http://dx.doi.org/10.1152/physrev.00023.2022
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author Jagannath, Aarti
Taylor, Lewis
Ru, Yining
Wakaf, Zeinab
Akpobaro, Kayomavua
Vasudevan, Sridhar
Foster, Russell G.
author_facet Jagannath, Aarti
Taylor, Lewis
Ru, Yining
Wakaf, Zeinab
Akpobaro, Kayomavua
Vasudevan, Sridhar
Foster, Russell G.
author_sort Jagannath, Aarti
collection PubMed
description Salt-inducible kinases (SIKs), which comprise a family of three homologous serine-threonine kinases, were first described for their role in sodium sensing but have since been shown to regulate multiple aspects of physiology. These kinases are activated or deactivated in response to extracellular signals that are cell surface receptor mediated and go on to phosphorylate multiple targets including the transcription cofactors CRTC1–3 and the class IIa histone deacetylases (HDACs). Thus, the SIK family conveys signals about the cellular environment to reprogram transcriptional and posttranscriptional processes in response. In this manner, SIKs have been shown to regulate metabolic responses to feeding/fasting, cell division and oncogenesis, inflammation, immune responses, and most recently, sleep and circadian rhythms. Sleep and circadian rhythms are master regulators of physiology and are exquisitely sensitive to regulation by environmental light and physiological signals such as the need for sleep. Salt-inducible kinases have been shown to be central to the molecular regulation of both these processes. Here, we summarize the molecular mechanisms by which SIKs control these different domains of physiology and highlight where there is mechanistic overlap with sleep/circadian rhythm control.
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spelling pubmed-101909462023-05-18 The multiple roles of salt-inducible kinases in regulating physiology Jagannath, Aarti Taylor, Lewis Ru, Yining Wakaf, Zeinab Akpobaro, Kayomavua Vasudevan, Sridhar Foster, Russell G. Physiol Rev Review Salt-inducible kinases (SIKs), which comprise a family of three homologous serine-threonine kinases, were first described for their role in sodium sensing but have since been shown to regulate multiple aspects of physiology. These kinases are activated or deactivated in response to extracellular signals that are cell surface receptor mediated and go on to phosphorylate multiple targets including the transcription cofactors CRTC1–3 and the class IIa histone deacetylases (HDACs). Thus, the SIK family conveys signals about the cellular environment to reprogram transcriptional and posttranscriptional processes in response. In this manner, SIKs have been shown to regulate metabolic responses to feeding/fasting, cell division and oncogenesis, inflammation, immune responses, and most recently, sleep and circadian rhythms. Sleep and circadian rhythms are master regulators of physiology and are exquisitely sensitive to regulation by environmental light and physiological signals such as the need for sleep. Salt-inducible kinases have been shown to be central to the molecular regulation of both these processes. Here, we summarize the molecular mechanisms by which SIKs control these different domains of physiology and highlight where there is mechanistic overlap with sleep/circadian rhythm control. American Physiological Society 2023-07-01 2023-02-02 /pmc/articles/PMC10190946/ /pubmed/36731029 http://dx.doi.org/10.1152/physrev.00023.2022 Text en Copyright © 2023 The Authors https://creativecommons.org/licenses/by/4.0/Licensed under Creative Commons Attribution CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/) . Published by the American Physiological Society.
spellingShingle Review
Jagannath, Aarti
Taylor, Lewis
Ru, Yining
Wakaf, Zeinab
Akpobaro, Kayomavua
Vasudevan, Sridhar
Foster, Russell G.
The multiple roles of salt-inducible kinases in regulating physiology
title The multiple roles of salt-inducible kinases in regulating physiology
title_full The multiple roles of salt-inducible kinases in regulating physiology
title_fullStr The multiple roles of salt-inducible kinases in regulating physiology
title_full_unstemmed The multiple roles of salt-inducible kinases in regulating physiology
title_short The multiple roles of salt-inducible kinases in regulating physiology
title_sort multiple roles of salt-inducible kinases in regulating physiology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10190946/
https://www.ncbi.nlm.nih.gov/pubmed/36731029
http://dx.doi.org/10.1152/physrev.00023.2022
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