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Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment

Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection‐caused oxidative stress. Early antioxidant intervention by removing excessively produced reactive oxygen and nitrogen species (RONS) is beneficial to the prevention and treatment of sepsis. Ho...

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Autores principales: Yang, Ji, Zhang, Ruofei, Zhao, Hanqing, Qi, Haifeng, Li, Jingyun, Li, Jian‐Feng, Zhou, Xinyao, Wang, Aiqin, Fan, Kelong, Yan, Xiyun, Zhang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191017/
https://www.ncbi.nlm.nih.gov/pubmed/37325607
http://dx.doi.org/10.1002/EXP.20210267
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author Yang, Ji
Zhang, Ruofei
Zhao, Hanqing
Qi, Haifeng
Li, Jingyun
Li, Jian‐Feng
Zhou, Xinyao
Wang, Aiqin
Fan, Kelong
Yan, Xiyun
Zhang, Tao
author_facet Yang, Ji
Zhang, Ruofei
Zhao, Hanqing
Qi, Haifeng
Li, Jingyun
Li, Jian‐Feng
Zhou, Xinyao
Wang, Aiqin
Fan, Kelong
Yan, Xiyun
Zhang, Tao
author_sort Yang, Ji
collection PubMed
description Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection‐caused oxidative stress. Early antioxidant intervention by removing excessively produced reactive oxygen and nitrogen species (RONS) is beneficial to the prevention and treatment of sepsis. However, traditional antioxidants have failed to improve patient outcomes due to insufficient activity and sustainability. Herein, by mimicking the electronic and structural characteristics of natural Cu‐only superoxide dismutase (SOD5), a single‐atom nanozyme (SAzyme) featuring coordinately unsaturated and atomically dispersed Cu‐N(4) site was synthesized for effective sepsis treatment. The de novo‐designed Cu‐SAzyme exhibits a superior SOD‐like activity to efficiently eliminate O(2) (•−), which is the source of multiple RONS, thus blocking the free radical chain reaction and subsequent inflammatory response in the early stage of sepsis. Moreover, the Cu‐SAzyme effectively harnessed systemic inflammation and multi‐organ injuries in sepsis animal models. These findings indicate that the developed Cu‐SAzyme possesses great potential as therapeutic nanomedicines for the treatment of sepsis.
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spelling pubmed-101910172023-06-14 Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment Yang, Ji Zhang, Ruofei Zhao, Hanqing Qi, Haifeng Li, Jingyun Li, Jian‐Feng Zhou, Xinyao Wang, Aiqin Fan, Kelong Yan, Xiyun Zhang, Tao Exploration (Beijing) Research Articles Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection‐caused oxidative stress. Early antioxidant intervention by removing excessively produced reactive oxygen and nitrogen species (RONS) is beneficial to the prevention and treatment of sepsis. However, traditional antioxidants have failed to improve patient outcomes due to insufficient activity and sustainability. Herein, by mimicking the electronic and structural characteristics of natural Cu‐only superoxide dismutase (SOD5), a single‐atom nanozyme (SAzyme) featuring coordinately unsaturated and atomically dispersed Cu‐N(4) site was synthesized for effective sepsis treatment. The de novo‐designed Cu‐SAzyme exhibits a superior SOD‐like activity to efficiently eliminate O(2) (•−), which is the source of multiple RONS, thus blocking the free radical chain reaction and subsequent inflammatory response in the early stage of sepsis. Moreover, the Cu‐SAzyme effectively harnessed systemic inflammation and multi‐organ injuries in sepsis animal models. These findings indicate that the developed Cu‐SAzyme possesses great potential as therapeutic nanomedicines for the treatment of sepsis. John Wiley and Sons Inc. 2022-07-13 /pmc/articles/PMC10191017/ /pubmed/37325607 http://dx.doi.org/10.1002/EXP.20210267 Text en © 2022 The Authors. Exploration published by Henan University and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Yang, Ji
Zhang, Ruofei
Zhao, Hanqing
Qi, Haifeng
Li, Jingyun
Li, Jian‐Feng
Zhou, Xinyao
Wang, Aiqin
Fan, Kelong
Yan, Xiyun
Zhang, Tao
Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment
title Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment
title_full Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment
title_fullStr Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment
title_full_unstemmed Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment
title_short Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment
title_sort bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191017/
https://www.ncbi.nlm.nih.gov/pubmed/37325607
http://dx.doi.org/10.1002/EXP.20210267
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