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Utility of Ultrasound Imaging Features in Diagnosis of Breast Cancer

Background Currently, breast cancer (BC) is considered one of the most prevalent cancer worldwide in women and represents a global health challenge. Early diagnosis is the keystone in the management of BC patients. This study aims to assess the utility of ultrasonography (US) features of malignancy...

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Autores principales: Alshoabi, Sultan A, Alareqi, Amal A, Alhazmi, Fahad H, Qurashi, Abdulaziz A, Omer, Awatif M, Hamid, Abdullgabbar M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191155/
https://www.ncbi.nlm.nih.gov/pubmed/37206514
http://dx.doi.org/10.7759/cureus.37691
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author Alshoabi, Sultan A
Alareqi, Amal A
Alhazmi, Fahad H
Qurashi, Abdulaziz A
Omer, Awatif M
Hamid, Abdullgabbar M
author_facet Alshoabi, Sultan A
Alareqi, Amal A
Alhazmi, Fahad H
Qurashi, Abdulaziz A
Omer, Awatif M
Hamid, Abdullgabbar M
author_sort Alshoabi, Sultan A
collection PubMed
description Background Currently, breast cancer (BC) is considered one of the most prevalent cancer worldwide in women and represents a global health challenge. Early diagnosis is the keystone in the management of BC patients. This study aims to assess the utility of ultrasonography (US) features of malignancy in the diagnosis of BC. Methods This retrospective cross-sectional study involved the electronic records of 326 female patients who were diagnosed with BC. A cross-tabulation test was performed to identify the association between the presence of each US feature (yes/no), and the final US diagnosis (benign/malignant). The strength of association of each feature was measured using the odds ratio (OR) which was assumed to be significant when > 1, with a 95% confidence interval (CI). Results The mean age of the female patients involved in this study was 45.36 ±12.16 years old (range, 17-90 years). Cross-tabulation test showed a significant association between the malignancy tumor and the irregular shape of the lesion (p < 0.001, OR=7.162, CI 2.726-18.814), non-circumscribed margins (p < 0.001, OR = 9.031, CI 3.200-25.489), tissue distortion (p < 0.001, OR = 18.095, CI 5.944-55.091), and the lymph node enlargement (p < 0.001, OR = 5.705, CI 2.332-13.960). Conclusion US imaging features of malignancy have a high sensitivity and positive predictive value for detection of the BC. However, the specificity of breast US imaging features is much lower because of the overlapping features in benign and malignant breast lesions. Breast lesions with an irregular shape, not circumscribed irregular or spiculated margins, hypo-echogenicity, tissue distortion, and those with lymphadenopathy have the highest likelihood of malignancy despite the low specificity. US is a highly valuable, safe, and affordable imaging modality with high diagnostic accuracy for BC.
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spelling pubmed-101911552023-05-18 Utility of Ultrasound Imaging Features in Diagnosis of Breast Cancer Alshoabi, Sultan A Alareqi, Amal A Alhazmi, Fahad H Qurashi, Abdulaziz A Omer, Awatif M Hamid, Abdullgabbar M Cureus Family/General Practice Background Currently, breast cancer (BC) is considered one of the most prevalent cancer worldwide in women and represents a global health challenge. Early diagnosis is the keystone in the management of BC patients. This study aims to assess the utility of ultrasonography (US) features of malignancy in the diagnosis of BC. Methods This retrospective cross-sectional study involved the electronic records of 326 female patients who were diagnosed with BC. A cross-tabulation test was performed to identify the association between the presence of each US feature (yes/no), and the final US diagnosis (benign/malignant). The strength of association of each feature was measured using the odds ratio (OR) which was assumed to be significant when > 1, with a 95% confidence interval (CI). Results The mean age of the female patients involved in this study was 45.36 ±12.16 years old (range, 17-90 years). Cross-tabulation test showed a significant association between the malignancy tumor and the irregular shape of the lesion (p < 0.001, OR=7.162, CI 2.726-18.814), non-circumscribed margins (p < 0.001, OR = 9.031, CI 3.200-25.489), tissue distortion (p < 0.001, OR = 18.095, CI 5.944-55.091), and the lymph node enlargement (p < 0.001, OR = 5.705, CI 2.332-13.960). Conclusion US imaging features of malignancy have a high sensitivity and positive predictive value for detection of the BC. However, the specificity of breast US imaging features is much lower because of the overlapping features in benign and malignant breast lesions. Breast lesions with an irregular shape, not circumscribed irregular or spiculated margins, hypo-echogenicity, tissue distortion, and those with lymphadenopathy have the highest likelihood of malignancy despite the low specificity. US is a highly valuable, safe, and affordable imaging modality with high diagnostic accuracy for BC. Cureus 2023-04-17 /pmc/articles/PMC10191155/ /pubmed/37206514 http://dx.doi.org/10.7759/cureus.37691 Text en Copyright © 2023, Alshoabi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Family/General Practice
Alshoabi, Sultan A
Alareqi, Amal A
Alhazmi, Fahad H
Qurashi, Abdulaziz A
Omer, Awatif M
Hamid, Abdullgabbar M
Utility of Ultrasound Imaging Features in Diagnosis of Breast Cancer
title Utility of Ultrasound Imaging Features in Diagnosis of Breast Cancer
title_full Utility of Ultrasound Imaging Features in Diagnosis of Breast Cancer
title_fullStr Utility of Ultrasound Imaging Features in Diagnosis of Breast Cancer
title_full_unstemmed Utility of Ultrasound Imaging Features in Diagnosis of Breast Cancer
title_short Utility of Ultrasound Imaging Features in Diagnosis of Breast Cancer
title_sort utility of ultrasound imaging features in diagnosis of breast cancer
topic Family/General Practice
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191155/
https://www.ncbi.nlm.nih.gov/pubmed/37206514
http://dx.doi.org/10.7759/cureus.37691
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