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Revisiting Aire and tissue-restricted antigens at single-cell resolution
The thymus is a highly specialized organ that plays an indispensable role in the establishment of self-tolerance, a process characterized by the “education” of developing T-cells. To provide competent T-cells tolerant to self-antigens, medullary thymic epithelial cells (mTECs) orchestrate negative s...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191227/ https://www.ncbi.nlm.nih.gov/pubmed/37207224 http://dx.doi.org/10.3389/fimmu.2023.1176450 |
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author | Matsumoto, Minoru Yoshida, Hideyuki Tsuneyama, Koichi Oya, Takeshi Matsumoto, Mitsuru |
author_facet | Matsumoto, Minoru Yoshida, Hideyuki Tsuneyama, Koichi Oya, Takeshi Matsumoto, Mitsuru |
author_sort | Matsumoto, Minoru |
collection | PubMed |
description | The thymus is a highly specialized organ that plays an indispensable role in the establishment of self-tolerance, a process characterized by the “education” of developing T-cells. To provide competent T-cells tolerant to self-antigens, medullary thymic epithelial cells (mTECs) orchestrate negative selection by ectopically expressing a wide range of genes, including various tissue-restricted antigens (TRAs). Notably, recent advancements in the high-throughput single-cell analysis have revealed remarkable heterogeneity in mTECs, giving us important clues for dissecting the mechanisms underlying TRA expression. We overview how recent single-cell studies have furthered our understanding of mTECs, with a focus on the role of Aire in inducing mTEC heterogeneity to encompass TRAs. |
format | Online Article Text |
id | pubmed-10191227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101912272023-05-18 Revisiting Aire and tissue-restricted antigens at single-cell resolution Matsumoto, Minoru Yoshida, Hideyuki Tsuneyama, Koichi Oya, Takeshi Matsumoto, Mitsuru Front Immunol Immunology The thymus is a highly specialized organ that plays an indispensable role in the establishment of self-tolerance, a process characterized by the “education” of developing T-cells. To provide competent T-cells tolerant to self-antigens, medullary thymic epithelial cells (mTECs) orchestrate negative selection by ectopically expressing a wide range of genes, including various tissue-restricted antigens (TRAs). Notably, recent advancements in the high-throughput single-cell analysis have revealed remarkable heterogeneity in mTECs, giving us important clues for dissecting the mechanisms underlying TRA expression. We overview how recent single-cell studies have furthered our understanding of mTECs, with a focus on the role of Aire in inducing mTEC heterogeneity to encompass TRAs. Frontiers Media S.A. 2023-05-03 /pmc/articles/PMC10191227/ /pubmed/37207224 http://dx.doi.org/10.3389/fimmu.2023.1176450 Text en Copyright © 2023 Matsumoto, Yoshida, Tsuneyama, Oya and Matsumoto https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Matsumoto, Minoru Yoshida, Hideyuki Tsuneyama, Koichi Oya, Takeshi Matsumoto, Mitsuru Revisiting Aire and tissue-restricted antigens at single-cell resolution |
title | Revisiting Aire and tissue-restricted antigens at single-cell resolution |
title_full | Revisiting Aire and tissue-restricted antigens at single-cell resolution |
title_fullStr | Revisiting Aire and tissue-restricted antigens at single-cell resolution |
title_full_unstemmed | Revisiting Aire and tissue-restricted antigens at single-cell resolution |
title_short | Revisiting Aire and tissue-restricted antigens at single-cell resolution |
title_sort | revisiting aire and tissue-restricted antigens at single-cell resolution |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191227/ https://www.ncbi.nlm.nih.gov/pubmed/37207224 http://dx.doi.org/10.3389/fimmu.2023.1176450 |
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