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Prospective acceptability of a multipurpose technology (MPT) implant in preclinical development to prevent HIV and unplanned pregnancy: Qualitative insights from women end users and health care providers in South Africa and Zimbabwe

BACKGROUND: Given the high rates of both HIV and unintended pregnancies in sub-Saharan Africa, the SCHIELD program aims to develop a multipurpose technology implant for HIV and pregnancy prevention. An end-user evaluation was undertaken with young women and health care providers to assess preference...

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Autores principales: Nkomo, Sikhanyisiwe, Makoni, Wanzirai, Shapley-Quinn, Mary Kate, Luecke, Ellen, Mbatsane, Enough, Manenzhe, Kgahlisho, Ahmed, Khatija, Johnson, Leah M., Mahaka, Imelda, van der Straten, Ariane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191314/
https://www.ncbi.nlm.nih.gov/pubmed/37195918
http://dx.doi.org/10.1371/journal.pone.0285711
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author Nkomo, Sikhanyisiwe
Makoni, Wanzirai
Shapley-Quinn, Mary Kate
Luecke, Ellen
Mbatsane, Enough
Manenzhe, Kgahlisho
Ahmed, Khatija
Johnson, Leah M.
Mahaka, Imelda
van der Straten, Ariane
author_facet Nkomo, Sikhanyisiwe
Makoni, Wanzirai
Shapley-Quinn, Mary Kate
Luecke, Ellen
Mbatsane, Enough
Manenzhe, Kgahlisho
Ahmed, Khatija
Johnson, Leah M.
Mahaka, Imelda
van der Straten, Ariane
author_sort Nkomo, Sikhanyisiwe
collection PubMed
description BACKGROUND: Given the high rates of both HIV and unintended pregnancies in sub-Saharan Africa, the SCHIELD program aims to develop a multipurpose technology implant for HIV and pregnancy prevention. An end-user evaluation was undertaken with young women and health care providers to assess preferences for modifiable implant attributes to improve future adoption and rollout. METHODS: Focus group discussions were conducted with potential women end users, and health care providers experienced in implant insertion or removal participated in in-depth interviews. All participants were recruited from Harare, Zimbabwe, or Soshanguve, South Africa. The purposively stratified sampled women were either implant experienced or implant naïve and were categorized into three groups: nulliparous, postpartum, or engaged in transactional sex. Topics covered included duration (six months to three years), biodegradability, removability, and independent rod retrievability (per indication). Data were analyzed using Dedoose software and summarized into emerging themes. RESULTS: Participants identified three key areas that could facilitate rollout, uptake, and adherence of an implant for HIV and pregnancy prevention. First, discreetness was the most salient topic and was associated with implant characteristics such as anatomical location, flexibility, and biodegradability. Second, the ability to independently retrieve the HIV or pregnancy prevention component was preferred, as life circumstances may change and was favored by all participants, except for young women in Soshanguve. Third, there is a need for proper counseling, sensitization, provider training, and health campaigns to facilitate rollout of a 2-in-1 implant. CONCLUSIONS: A 2-in-1 implant was seen as highly desirable by most young women and health care providers. Participants discussed potential concerns and barriers to uptake of a biodegradable implant with dual HIV prevention and contraceptive properties, identifying key implant attributes that product developers can modify while still in preclinical stages.
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spelling pubmed-101913142023-05-18 Prospective acceptability of a multipurpose technology (MPT) implant in preclinical development to prevent HIV and unplanned pregnancy: Qualitative insights from women end users and health care providers in South Africa and Zimbabwe Nkomo, Sikhanyisiwe Makoni, Wanzirai Shapley-Quinn, Mary Kate Luecke, Ellen Mbatsane, Enough Manenzhe, Kgahlisho Ahmed, Khatija Johnson, Leah M. Mahaka, Imelda van der Straten, Ariane PLoS One Research Article BACKGROUND: Given the high rates of both HIV and unintended pregnancies in sub-Saharan Africa, the SCHIELD program aims to develop a multipurpose technology implant for HIV and pregnancy prevention. An end-user evaluation was undertaken with young women and health care providers to assess preferences for modifiable implant attributes to improve future adoption and rollout. METHODS: Focus group discussions were conducted with potential women end users, and health care providers experienced in implant insertion or removal participated in in-depth interviews. All participants were recruited from Harare, Zimbabwe, or Soshanguve, South Africa. The purposively stratified sampled women were either implant experienced or implant naïve and were categorized into three groups: nulliparous, postpartum, or engaged in transactional sex. Topics covered included duration (six months to three years), biodegradability, removability, and independent rod retrievability (per indication). Data were analyzed using Dedoose software and summarized into emerging themes. RESULTS: Participants identified three key areas that could facilitate rollout, uptake, and adherence of an implant for HIV and pregnancy prevention. First, discreetness was the most salient topic and was associated with implant characteristics such as anatomical location, flexibility, and biodegradability. Second, the ability to independently retrieve the HIV or pregnancy prevention component was preferred, as life circumstances may change and was favored by all participants, except for young women in Soshanguve. Third, there is a need for proper counseling, sensitization, provider training, and health campaigns to facilitate rollout of a 2-in-1 implant. CONCLUSIONS: A 2-in-1 implant was seen as highly desirable by most young women and health care providers. Participants discussed potential concerns and barriers to uptake of a biodegradable implant with dual HIV prevention and contraceptive properties, identifying key implant attributes that product developers can modify while still in preclinical stages. Public Library of Science 2023-05-17 /pmc/articles/PMC10191314/ /pubmed/37195918 http://dx.doi.org/10.1371/journal.pone.0285711 Text en © 2023 Nkomo et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nkomo, Sikhanyisiwe
Makoni, Wanzirai
Shapley-Quinn, Mary Kate
Luecke, Ellen
Mbatsane, Enough
Manenzhe, Kgahlisho
Ahmed, Khatija
Johnson, Leah M.
Mahaka, Imelda
van der Straten, Ariane
Prospective acceptability of a multipurpose technology (MPT) implant in preclinical development to prevent HIV and unplanned pregnancy: Qualitative insights from women end users and health care providers in South Africa and Zimbabwe
title Prospective acceptability of a multipurpose technology (MPT) implant in preclinical development to prevent HIV and unplanned pregnancy: Qualitative insights from women end users and health care providers in South Africa and Zimbabwe
title_full Prospective acceptability of a multipurpose technology (MPT) implant in preclinical development to prevent HIV and unplanned pregnancy: Qualitative insights from women end users and health care providers in South Africa and Zimbabwe
title_fullStr Prospective acceptability of a multipurpose technology (MPT) implant in preclinical development to prevent HIV and unplanned pregnancy: Qualitative insights from women end users and health care providers in South Africa and Zimbabwe
title_full_unstemmed Prospective acceptability of a multipurpose technology (MPT) implant in preclinical development to prevent HIV and unplanned pregnancy: Qualitative insights from women end users and health care providers in South Africa and Zimbabwe
title_short Prospective acceptability of a multipurpose technology (MPT) implant in preclinical development to prevent HIV and unplanned pregnancy: Qualitative insights from women end users and health care providers in South Africa and Zimbabwe
title_sort prospective acceptability of a multipurpose technology (mpt) implant in preclinical development to prevent hiv and unplanned pregnancy: qualitative insights from women end users and health care providers in south africa and zimbabwe
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191314/
https://www.ncbi.nlm.nih.gov/pubmed/37195918
http://dx.doi.org/10.1371/journal.pone.0285711
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