Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients

Drug repurposing requires distinguishing established drug class targets from novel molecule-specific mechanisms and rapidly derisking their therapeutic potential in a time-critical manner, particularly in a pandemic scenario. In response to the challenge to rapidly identify treatment options for COV...

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Detalles Bibliográficos
Autores principales: Sperry, Megan M., Oskotsky, Tomiko T., Marić, Ivana, Kaushal, Shruti, Takeda, Takako, Horvath, Viktor, Powers, Rani K., Rodas, Melissa, Furlong, Brooke, Soong, Mercy, Prabhala, Pranav, Goyal, Girija, Carlson, Kenneth E., Wong, Ronald J., Kosti, Idit, Le, Brian L., Logue, James, Hammond, Holly, Frieman, Matthew, Stevenson, David K., Ingber, Donald E., Sirota, Marina, Novak, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191356/
https://www.ncbi.nlm.nih.gov/pubmed/37146076
http://dx.doi.org/10.1371/journal.pcbi.1011050

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