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CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy

Synonymous recoding of RNA virus genomes is a promising approach for generating attenuated viruses to use as vaccines. Problematically, recoding typically hinders virus growth, but this may be rectified using CpG dinucleotide enrichment. CpGs are recognised by cellular zinc-finger antiviral protein...

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Detalles Bibliográficos
Autores principales:	Sharp, Colin P., Thompson, Beth H., Nash, Tessa J., Diebold, Ola, Pinto, Rute M., Thorley, Luke, Lin, Yao-Tang, Sives, Samantha, Wise, Helen, Clohisey Hendry, Sara, Grey, Finn, Vervelde, Lonneke, Simmonds, Peter, Digard, Paul, Gaunt, Eleanor R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191365/ https://www.ncbi.nlm.nih.gov/pubmed/37146066 http://dx.doi.org/10.1371/journal.ppat.1011357

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