The C-terminal 32-mer fragment of hemoglobin alpha is an amyloidogenic peptide with antimicrobial properties

Antimicrobial peptides (AMPs) are major components of the innate immune defense. Accumulating evidence suggests that the antibacterial activity of many AMPs is dependent on the formation of amyloid-like fibrils. To identify novel fibril forming AMPs, we generated a spleen-derived peptide library and...

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Detalles Bibliográficos
Autores principales: Olari, Lia-Raluca, Bauer, Richard, Gil Miró, Marta, Vogel, Verena, Cortez Rayas, Laura, Groß, Rüdiger, Gilg, Andrea, Klevesath, Raphael, Rodríguez Alfonso, Armando A., Kaygisiz, Kübra, Rupp, Ulrich, Pant, Pradeep, Mieres-Pérez, Joel, Steppe, Lena, Schäffer, Ramona, Rauch-Wirth, Lena, Conzelmann, Carina, Müller, Janis A., Zech, Fabian, Gerbl, Fabian, Bleher, Jana, Preising, Nico, Ständker, Ludger, Wiese, Sebastian, Thal, Dietmar R., Haupt, Christian, Jonker, Hendrik R. A., Wagner, Manfred, Sanchez-Garcia, Elsa, Weil, Tanja, Stenger, Steffen, Fändrich, Marcus, von Einem, Jens, Read, Clarissa, Walther, Paul, Kirchhoff, Frank, Spellerberg, Barbara, Münch, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191403/
https://www.ncbi.nlm.nih.gov/pubmed/37198527
http://dx.doi.org/10.1007/s00018-023-04795-8

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