Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production

During therapy, adaptations driven by cellular plasticity are partly responsible for driving the inevitable recurrence of glioblastoma (GBM). To investigate plasticity-induced adaptation during standard-of-care chemotherapy temozolomide (TMZ), we performed in vivo single-cell RNA sequencing in patie...

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Detalles Bibliográficos
Autores principales: Perrault, Ella N., Shireman, Jack M., Ali, Eunus S., Lin, Peiyu, Preddy, Isabelle, Park, Cheol, Budhiraja, Shreya, Baisiwala, Shivani, Dixit, Karan, James, C. David, Heiland, Dieter H, Ben-Sahra, Issam, Pott, Sebastian, Basu, Anindita, Miska, Jason, Ahmed, Atique U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191446/
https://www.ncbi.nlm.nih.gov/pubmed/37196077
http://dx.doi.org/10.1126/sciadv.ade7236

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