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Intestinal Fatty Acid Binding Protein Levels in Pediatric Celiac Patients in Transition From Active Disease to Clinical and Serological Remission

Celiac disease (CD) is increasingly diagnosed without endoscopy. As such, the need for accurate serological markers to aid in the diagnosis and follow-up of CD has increased. Intestinal fatty acid binding protein (I-FABP) is a cytosolic protein present in enterocytes, whose blood levels reflect muco...

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Autores principales: Hoofien, Assaf, Guz-Mark, Anat, Zevit, Noam, Tsadok Perets, Tsachi, Assa, Amit, Layfer, Olga, Matar, Manar, Nachmias-Friedler, Vered, Silbermintz, Ari, Shamir, Raanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191526/
https://www.ncbi.nlm.nih.gov/pubmed/37207053
http://dx.doi.org/10.1097/PG9.0000000000000070
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author Hoofien, Assaf
Guz-Mark, Anat
Zevit, Noam
Tsadok Perets, Tsachi
Assa, Amit
Layfer, Olga
Matar, Manar
Nachmias-Friedler, Vered
Silbermintz, Ari
Shamir, Raanan
author_facet Hoofien, Assaf
Guz-Mark, Anat
Zevit, Noam
Tsadok Perets, Tsachi
Assa, Amit
Layfer, Olga
Matar, Manar
Nachmias-Friedler, Vered
Silbermintz, Ari
Shamir, Raanan
author_sort Hoofien, Assaf
collection PubMed
description Celiac disease (CD) is increasingly diagnosed without endoscopy. As such, the need for accurate serological markers to aid in the diagnosis and follow-up of CD has increased. Intestinal fatty acid binding protein (I-FABP) is a cytosolic protein present in enterocytes, whose blood levels reflect mucosal damage in a reliable and quantifiable way. The aim of this study was to compare I-FABP levels in newly diagnosed patients with CD and to examine changes in levels following 6 months of gluten-free diet (GFD). METHODS: A prospective observational case control study of pediatric patients diagnosed with CD, with measurements of tissue transglutaminase IgA (TTG-IgA) and I-FABP levels at diagnosis and after 6 months of gluten free diet were compared to a control group of nonceliac patients. RESULTS: This study included 35 patients and 32 controls. The CD group had higher I-FABP levels at diagnosis compared with the control group (median 641.7 pg/mL versus 334 pg/mL; P < 0.05). I-FABP levels significantly differed between patients presenting with TTG-IgA level 3–10 times the upper limit of normal (ULN) compared with those presenting with values >10 times ULN (median 432.2 pg/mL versus 796.2 pg/mL; P < 0.05). Patients with CD had a significant decrease in median I-FABP levels after 6 months of GFD (median 268.2 pg/mL), paralleling a decrease in TTG-IgA and GFD adherence. CONCLUSIONS: I-FABP levels are increased in patients with CD at diagnosis compared with controls and decrease significantly while patients adhere to GFD.
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spelling pubmed-101915262023-05-18 Intestinal Fatty Acid Binding Protein Levels in Pediatric Celiac Patients in Transition From Active Disease to Clinical and Serological Remission Hoofien, Assaf Guz-Mark, Anat Zevit, Noam Tsadok Perets, Tsachi Assa, Amit Layfer, Olga Matar, Manar Nachmias-Friedler, Vered Silbermintz, Ari Shamir, Raanan JPGN Rep Original Article Celiac disease (CD) is increasingly diagnosed without endoscopy. As such, the need for accurate serological markers to aid in the diagnosis and follow-up of CD has increased. Intestinal fatty acid binding protein (I-FABP) is a cytosolic protein present in enterocytes, whose blood levels reflect mucosal damage in a reliable and quantifiable way. The aim of this study was to compare I-FABP levels in newly diagnosed patients with CD and to examine changes in levels following 6 months of gluten-free diet (GFD). METHODS: A prospective observational case control study of pediatric patients diagnosed with CD, with measurements of tissue transglutaminase IgA (TTG-IgA) and I-FABP levels at diagnosis and after 6 months of gluten free diet were compared to a control group of nonceliac patients. RESULTS: This study included 35 patients and 32 controls. The CD group had higher I-FABP levels at diagnosis compared with the control group (median 641.7 pg/mL versus 334 pg/mL; P < 0.05). I-FABP levels significantly differed between patients presenting with TTG-IgA level 3–10 times the upper limit of normal (ULN) compared with those presenting with values >10 times ULN (median 432.2 pg/mL versus 796.2 pg/mL; P < 0.05). Patients with CD had a significant decrease in median I-FABP levels after 6 months of GFD (median 268.2 pg/mL), paralleling a decrease in TTG-IgA and GFD adherence. CONCLUSIONS: I-FABP levels are increased in patients with CD at diagnosis compared with controls and decrease significantly while patients adhere to GFD. Lippincott Williams & Wilkins, Inc. 2021-03-30 /pmc/articles/PMC10191526/ /pubmed/37207053 http://dx.doi.org/10.1097/PG9.0000000000000070 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hoofien, Assaf
Guz-Mark, Anat
Zevit, Noam
Tsadok Perets, Tsachi
Assa, Amit
Layfer, Olga
Matar, Manar
Nachmias-Friedler, Vered
Silbermintz, Ari
Shamir, Raanan
Intestinal Fatty Acid Binding Protein Levels in Pediatric Celiac Patients in Transition From Active Disease to Clinical and Serological Remission
title Intestinal Fatty Acid Binding Protein Levels in Pediatric Celiac Patients in Transition From Active Disease to Clinical and Serological Remission
title_full Intestinal Fatty Acid Binding Protein Levels in Pediatric Celiac Patients in Transition From Active Disease to Clinical and Serological Remission
title_fullStr Intestinal Fatty Acid Binding Protein Levels in Pediatric Celiac Patients in Transition From Active Disease to Clinical and Serological Remission
title_full_unstemmed Intestinal Fatty Acid Binding Protein Levels in Pediatric Celiac Patients in Transition From Active Disease to Clinical and Serological Remission
title_short Intestinal Fatty Acid Binding Protein Levels in Pediatric Celiac Patients in Transition From Active Disease to Clinical and Serological Remission
title_sort intestinal fatty acid binding protein levels in pediatric celiac patients in transition from active disease to clinical and serological remission
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191526/
https://www.ncbi.nlm.nih.gov/pubmed/37207053
http://dx.doi.org/10.1097/PG9.0000000000000070
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