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Chronic Recurrent Multifocal Osteomyelitis in Pediatric Crohn Disease, A Paradoxical Effect to Antitumor Necrosis Factor Alpha
Tumor necrosis factor-α (TNF-α) inhibitors have resulted in significant progress in the treatment of chronic inflammatory diseases. However, these therapies can lead to paradoxical immune-mediated inflammatory diseases with unknown physiopathology. For the first time, we report 3 cases of paradoxica...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191537/ https://www.ncbi.nlm.nih.gov/pubmed/37206602 http://dx.doi.org/10.1097/PG9.0000000000000007 |
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author | Cordesse, Anne Ecochard-Dugelay, Emmanuelle Melki, Isabelle Caseris, Marion Belarbi, Nadia Hugot, Jean-Pierre Viala, Jerome Martinez-Vinson, Christine |
author_facet | Cordesse, Anne Ecochard-Dugelay, Emmanuelle Melki, Isabelle Caseris, Marion Belarbi, Nadia Hugot, Jean-Pierre Viala, Jerome Martinez-Vinson, Christine |
author_sort | Cordesse, Anne |
collection | PubMed |
description | Tumor necrosis factor-α (TNF-α) inhibitors have resulted in significant progress in the treatment of chronic inflammatory diseases. However, these therapies can lead to paradoxical immune-mediated inflammatory diseases with unknown physiopathology. For the first time, we report 3 cases of paradoxical chronic recurrent multifocal osteomyelitis after infliximab or adalimumab therapy during the course of Crohn disease. The patients complained of bone pain without joint involvement. At the time of diagnosis of paradoxical reaction, all patients were in remission due to anti-TNFα efficiency. Trough levels of anti-TNFα were in the expected range, and there were no anti–anti-TNFα antibodies. The duration of treatment was between 2 and 26 months. Other causes of CRMO were excluded. All patients recovered after discontinuation of infliximab (n = 2) or adalimumab (n = 1). The increasing use of these therapies leads to new descriptions of paradoxical effects, which clinicians should be aware of. |
format | Online Article Text |
id | pubmed-10191537 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-101915372023-05-18 Chronic Recurrent Multifocal Osteomyelitis in Pediatric Crohn Disease, A Paradoxical Effect to Antitumor Necrosis Factor Alpha Cordesse, Anne Ecochard-Dugelay, Emmanuelle Melki, Isabelle Caseris, Marion Belarbi, Nadia Hugot, Jean-Pierre Viala, Jerome Martinez-Vinson, Christine JPGN Rep Case Report Tumor necrosis factor-α (TNF-α) inhibitors have resulted in significant progress in the treatment of chronic inflammatory diseases. However, these therapies can lead to paradoxical immune-mediated inflammatory diseases with unknown physiopathology. For the first time, we report 3 cases of paradoxical chronic recurrent multifocal osteomyelitis after infliximab or adalimumab therapy during the course of Crohn disease. The patients complained of bone pain without joint involvement. At the time of diagnosis of paradoxical reaction, all patients were in remission due to anti-TNFα efficiency. Trough levels of anti-TNFα were in the expected range, and there were no anti–anti-TNFα antibodies. The duration of treatment was between 2 and 26 months. Other causes of CRMO were excluded. All patients recovered after discontinuation of infliximab (n = 2) or adalimumab (n = 1). The increasing use of these therapies leads to new descriptions of paradoxical effects, which clinicians should be aware of. Lippincott Williams & Wilkins 2020-08-20 /pmc/articles/PMC10191537/ /pubmed/37206602 http://dx.doi.org/10.1097/PG9.0000000000000007 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Cordesse, Anne Ecochard-Dugelay, Emmanuelle Melki, Isabelle Caseris, Marion Belarbi, Nadia Hugot, Jean-Pierre Viala, Jerome Martinez-Vinson, Christine Chronic Recurrent Multifocal Osteomyelitis in Pediatric Crohn Disease, A Paradoxical Effect to Antitumor Necrosis Factor Alpha |
title | Chronic Recurrent Multifocal Osteomyelitis in Pediatric Crohn Disease, A Paradoxical Effect to Antitumor Necrosis Factor Alpha |
title_full | Chronic Recurrent Multifocal Osteomyelitis in Pediatric Crohn Disease, A Paradoxical Effect to Antitumor Necrosis Factor Alpha |
title_fullStr | Chronic Recurrent Multifocal Osteomyelitis in Pediatric Crohn Disease, A Paradoxical Effect to Antitumor Necrosis Factor Alpha |
title_full_unstemmed | Chronic Recurrent Multifocal Osteomyelitis in Pediatric Crohn Disease, A Paradoxical Effect to Antitumor Necrosis Factor Alpha |
title_short | Chronic Recurrent Multifocal Osteomyelitis in Pediatric Crohn Disease, A Paradoxical Effect to Antitumor Necrosis Factor Alpha |
title_sort | chronic recurrent multifocal osteomyelitis in pediatric crohn disease, a paradoxical effect to antitumor necrosis factor alpha |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191537/ https://www.ncbi.nlm.nih.gov/pubmed/37206602 http://dx.doi.org/10.1097/PG9.0000000000000007 |
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