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Seizure During Infliximab Infusion in a Child With Crohn’s Disease: An Illustration of a Neurologic Adverse Event Associated With Drug Antibodies
Antitumor necrosis factor (anti-TNF) therapy has proven efficacy in the induction and maintenance of remission in children with Crohn’s disease (CD). With the increased use of these medications, several adverse events have been associated, including the emergence of neurologic side effects. While de...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191561/ https://www.ncbi.nlm.nih.gov/pubmed/37205948 http://dx.doi.org/10.1097/PG9.0000000000000101 |
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author | Joseph, Shelly Reed, Anna W Cuffari, Carmen |
author_facet | Joseph, Shelly Reed, Anna W Cuffari, Carmen |
author_sort | Joseph, Shelly |
collection | PubMed |
description | Antitumor necrosis factor (anti-TNF) therapy has proven efficacy in the induction and maintenance of remission in children with Crohn’s disease (CD). With the increased use of these medications, several adverse events have been associated, including the emergence of neurologic side effects. While demyelinating conditions and neuropathy associated with anti-TNF therapy have been reported in adults, seizures have been anecdotally described in case reports. We describe a case of an adolescent boy who experienced an infliximab-associated seizure during an infusion and the potential role that medication antibody levels may have played in this adverse event. |
format | Online Article Text |
id | pubmed-10191561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101915612023-05-18 Seizure During Infliximab Infusion in a Child With Crohn’s Disease: An Illustration of a Neurologic Adverse Event Associated With Drug Antibodies Joseph, Shelly Reed, Anna W Cuffari, Carmen JPGN Rep Case Report Antitumor necrosis factor (anti-TNF) therapy has proven efficacy in the induction and maintenance of remission in children with Crohn’s disease (CD). With the increased use of these medications, several adverse events have been associated, including the emergence of neurologic side effects. While demyelinating conditions and neuropathy associated with anti-TNF therapy have been reported in adults, seizures have been anecdotally described in case reports. We describe a case of an adolescent boy who experienced an infliximab-associated seizure during an infusion and the potential role that medication antibody levels may have played in this adverse event. Lippincott Williams & Wilkins, Inc. 2021-07-12 /pmc/articles/PMC10191561/ /pubmed/37205948 http://dx.doi.org/10.1097/PG9.0000000000000101 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Case Report Joseph, Shelly Reed, Anna W Cuffari, Carmen Seizure During Infliximab Infusion in a Child With Crohn’s Disease: An Illustration of a Neurologic Adverse Event Associated With Drug Antibodies |
title | Seizure During Infliximab Infusion in a Child With Crohn’s Disease: An Illustration of a Neurologic Adverse Event Associated With Drug Antibodies |
title_full | Seizure During Infliximab Infusion in a Child With Crohn’s Disease: An Illustration of a Neurologic Adverse Event Associated With Drug Antibodies |
title_fullStr | Seizure During Infliximab Infusion in a Child With Crohn’s Disease: An Illustration of a Neurologic Adverse Event Associated With Drug Antibodies |
title_full_unstemmed | Seizure During Infliximab Infusion in a Child With Crohn’s Disease: An Illustration of a Neurologic Adverse Event Associated With Drug Antibodies |
title_short | Seizure During Infliximab Infusion in a Child With Crohn’s Disease: An Illustration of a Neurologic Adverse Event Associated With Drug Antibodies |
title_sort | seizure during infliximab infusion in a child with crohn’s disease: an illustration of a neurologic adverse event associated with drug antibodies |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191561/ https://www.ncbi.nlm.nih.gov/pubmed/37205948 http://dx.doi.org/10.1097/PG9.0000000000000101 |
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