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Seizure During Infliximab Infusion in a Child With Crohn’s Disease: An Illustration of a Neurologic Adverse Event Associated With Drug Antibodies

Antitumor necrosis factor (anti-TNF) therapy has proven efficacy in the induction and maintenance of remission in children with Crohn’s disease (CD). With the increased use of these medications, several adverse events have been associated, including the emergence of neurologic side effects. While de...

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Detalles Bibliográficos
Autores principales: Joseph, Shelly, Reed, Anna W, Cuffari, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191561/
https://www.ncbi.nlm.nih.gov/pubmed/37205948
http://dx.doi.org/10.1097/PG9.0000000000000101
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author Joseph, Shelly
Reed, Anna W
Cuffari, Carmen
author_facet Joseph, Shelly
Reed, Anna W
Cuffari, Carmen
author_sort Joseph, Shelly
collection PubMed
description Antitumor necrosis factor (anti-TNF) therapy has proven efficacy in the induction and maintenance of remission in children with Crohn’s disease (CD). With the increased use of these medications, several adverse events have been associated, including the emergence of neurologic side effects. While demyelinating conditions and neuropathy associated with anti-TNF therapy have been reported in adults, seizures have been anecdotally described in case reports. We describe a case of an adolescent boy who experienced an infliximab-associated seizure during an infusion and the potential role that medication antibody levels may have played in this adverse event.
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spelling pubmed-101915612023-05-18 Seizure During Infliximab Infusion in a Child With Crohn’s Disease: An Illustration of a Neurologic Adverse Event Associated With Drug Antibodies Joseph, Shelly Reed, Anna W Cuffari, Carmen JPGN Rep Case Report Antitumor necrosis factor (anti-TNF) therapy has proven efficacy in the induction and maintenance of remission in children with Crohn’s disease (CD). With the increased use of these medications, several adverse events have been associated, including the emergence of neurologic side effects. While demyelinating conditions and neuropathy associated with anti-TNF therapy have been reported in adults, seizures have been anecdotally described in case reports. We describe a case of an adolescent boy who experienced an infliximab-associated seizure during an infusion and the potential role that medication antibody levels may have played in this adverse event. Lippincott Williams & Wilkins, Inc. 2021-07-12 /pmc/articles/PMC10191561/ /pubmed/37205948 http://dx.doi.org/10.1097/PG9.0000000000000101 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Joseph, Shelly
Reed, Anna W
Cuffari, Carmen
Seizure During Infliximab Infusion in a Child With Crohn’s Disease: An Illustration of a Neurologic Adverse Event Associated With Drug Antibodies
title Seizure During Infliximab Infusion in a Child With Crohn’s Disease: An Illustration of a Neurologic Adverse Event Associated With Drug Antibodies
title_full Seizure During Infliximab Infusion in a Child With Crohn’s Disease: An Illustration of a Neurologic Adverse Event Associated With Drug Antibodies
title_fullStr Seizure During Infliximab Infusion in a Child With Crohn’s Disease: An Illustration of a Neurologic Adverse Event Associated With Drug Antibodies
title_full_unstemmed Seizure During Infliximab Infusion in a Child With Crohn’s Disease: An Illustration of a Neurologic Adverse Event Associated With Drug Antibodies
title_short Seizure During Infliximab Infusion in a Child With Crohn’s Disease: An Illustration of a Neurologic Adverse Event Associated With Drug Antibodies
title_sort seizure during infliximab infusion in a child with crohn’s disease: an illustration of a neurologic adverse event associated with drug antibodies
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191561/
https://www.ncbi.nlm.nih.gov/pubmed/37205948
http://dx.doi.org/10.1097/PG9.0000000000000101
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