Acute Liver Failure in a Healthy Young Female With COVID-19

Several well-described manifestations of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported. Among them, a transient elevation of liver enzymes is the typical presentation of coronavirus disease 2019 (COVID-19) liver-related injury. The mechanism of liver...

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Detalles Bibliográficos
Autores principales: Orandi, Babak John, Li, Geling, Dhall, Deepti, Bajpai, Prachi, Manne, Upender, Arora, Nitin, Lu, Ailing, Coronado, Ana Carolina, Kassel, Rachel, Pinninti, Swetha, Lewis, Cora Elizabeth, Chapleau, Christopher, Locke, Jayme Elizabeth, Gutierrez Sanchez, Luz Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins, Inc. 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191572/
https://www.ncbi.nlm.nih.gov/pubmed/37205955
http://dx.doi.org/10.1097/PG9.0000000000000108
Descripción
Sumario:Several well-described manifestations of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported. Among them, a transient elevation of liver enzymes is the typical presentation of coronavirus disease 2019 (COVID-19) liver-related injury. The mechanism of liver involvement is likely a combination of viral injury and immune-mediated inflammation. In contrast, acute liver failure in the setting of COVID-19 has rarely been reported. Herein, we report a case of pediatric acute liver failure in a previously healthy female adolescent infected with SARS-CoV-2 with biopsy evidence of replicating virus in hepatocytes, which has not been previously reported.

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