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Clinical Features and Outcomes of Very-Early-Onset Inflammatory Bowel Disease in Brazilian Children

We report on 20 Brazilian children under 6 years of age with very-early-onset inflammatory bowel disease naive to treatment. The clinical, laboratory, and histopathologic findings at diagnosis and outcomes were reviewed: 13 had ulcerative colitis (UC) and 7 had Crohn disease (CD). The final diagnost...

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Autores principales: Penatti, Debora Avellaneda, Machado, Nilton Carlos, Carvalho, Mary Assis, Rodrigues, Maria Aparecida Marchesan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191598/
https://www.ncbi.nlm.nih.gov/pubmed/37206943
http://dx.doi.org/10.1097/PG9.0000000000000032
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author Penatti, Debora Avellaneda
Machado, Nilton Carlos
Carvalho, Mary Assis
Rodrigues, Maria Aparecida Marchesan
author_facet Penatti, Debora Avellaneda
Machado, Nilton Carlos
Carvalho, Mary Assis
Rodrigues, Maria Aparecida Marchesan
author_sort Penatti, Debora Avellaneda
collection PubMed
description We report on 20 Brazilian children under 6 years of age with very-early-onset inflammatory bowel disease naive to treatment. The clinical, laboratory, and histopathologic findings at diagnosis and outcomes were reviewed: 13 had ulcerative colitis (UC) and 7 had Crohn disease (CD). The final diagnostic pattern was as follows: 4 children had neonatal-onset (1 UC and 3 CD), 8 had infantile subtype (4 UC and 4 CD), and 8 had UC beyond the neonatal and infantile period. Both forms of inflammatory bowel disease were severe and extensive at diagnosis, with a high prevalence of bloody diarrhea, reflecting the colonic location of the disease. UC was predominantly pancolonic, CD was isolated in the colon and associated with perianal disease. Children with CD were younger than those with UC, were significantly more nutritionally impaired, and had more complications. This study shows that very-early-onset inflammatory bowel disease has an aggressive clinical course with 2 distinct phenotypes, UC and CD, with differences in severity, clinical behavior, and inflammatory pattern but with a preponderance of colonic involvement in both types.
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spelling pubmed-101915982023-05-18 Clinical Features and Outcomes of Very-Early-Onset Inflammatory Bowel Disease in Brazilian Children Penatti, Debora Avellaneda Machado, Nilton Carlos Carvalho, Mary Assis Rodrigues, Maria Aparecida Marchesan JPGN Rep Brief Report We report on 20 Brazilian children under 6 years of age with very-early-onset inflammatory bowel disease naive to treatment. The clinical, laboratory, and histopathologic findings at diagnosis and outcomes were reviewed: 13 had ulcerative colitis (UC) and 7 had Crohn disease (CD). The final diagnostic pattern was as follows: 4 children had neonatal-onset (1 UC and 3 CD), 8 had infantile subtype (4 UC and 4 CD), and 8 had UC beyond the neonatal and infantile period. Both forms of inflammatory bowel disease were severe and extensive at diagnosis, with a high prevalence of bloody diarrhea, reflecting the colonic location of the disease. UC was predominantly pancolonic, CD was isolated in the colon and associated with perianal disease. Children with CD were younger than those with UC, were significantly more nutritionally impaired, and had more complications. This study shows that very-early-onset inflammatory bowel disease has an aggressive clinical course with 2 distinct phenotypes, UC and CD, with differences in severity, clinical behavior, and inflammatory pattern but with a preponderance of colonic involvement in both types. Lippincott Williams & Wilkins, Inc. 2020-12-23 /pmc/articles/PMC10191598/ /pubmed/37206943 http://dx.doi.org/10.1097/PG9.0000000000000032 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Penatti, Debora Avellaneda
Machado, Nilton Carlos
Carvalho, Mary Assis
Rodrigues, Maria Aparecida Marchesan
Clinical Features and Outcomes of Very-Early-Onset Inflammatory Bowel Disease in Brazilian Children
title Clinical Features and Outcomes of Very-Early-Onset Inflammatory Bowel Disease in Brazilian Children
title_full Clinical Features and Outcomes of Very-Early-Onset Inflammatory Bowel Disease in Brazilian Children
title_fullStr Clinical Features and Outcomes of Very-Early-Onset Inflammatory Bowel Disease in Brazilian Children
title_full_unstemmed Clinical Features and Outcomes of Very-Early-Onset Inflammatory Bowel Disease in Brazilian Children
title_short Clinical Features and Outcomes of Very-Early-Onset Inflammatory Bowel Disease in Brazilian Children
title_sort clinical features and outcomes of very-early-onset inflammatory bowel disease in brazilian children
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191598/
https://www.ncbi.nlm.nih.gov/pubmed/37206943
http://dx.doi.org/10.1097/PG9.0000000000000032
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