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Systematic review of the association between isolated musculoskeletal hypermobility and adolescent idiopathic scoliosis

INTRODUCTION: Adolescent idiopathic scoliosis (AIS) affects 1–3% of the population, but its pathogenesis remains unclear. The coexistence of musculoskeletal hypermobility and scoliosis in many inherited syndromes raises the possibility that isolated musculoskeletal hypermobility may contribute to AI...

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Autores principales: Shere, Clare, Clark, Emma M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192177/
https://www.ncbi.nlm.nih.gov/pubmed/35841409
http://dx.doi.org/10.1007/s00402-022-04508-z
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author Shere, Clare
Clark, Emma M.
author_facet Shere, Clare
Clark, Emma M.
author_sort Shere, Clare
collection PubMed
description INTRODUCTION: Adolescent idiopathic scoliosis (AIS) affects 1–3% of the population, but its pathogenesis remains unclear. The coexistence of musculoskeletal hypermobility and scoliosis in many inherited syndromes raises the possibility that isolated musculoskeletal hypermobility may contribute to AIS development or progression. METHODS: We performed a systematic review of the evidence for a relationship between isolated musculoskeletal hypermobility and AIS. A meta-analysis was planned, but if not possible, a narrative evidence synthesis was planned. RESULTS: Nineteen studies met eligibility criteria for inclusion. One study was excluded due to insufficient quality. Substantial heterogeneity in study design and methodology negated meta-analysis, so a narrative review was performed. Of the 18 studies included, seven suggested a positive association and eight found no association. Three reported the prevalence of musculoskeletal hypermobility in individuals with AIS. Overall, there was no convincing population-based evidence for an association between musculoskeletal hypermobility and AIS, with only two case–control studies by the same authors presenting compelling evidence for an association. Although populations at extremes of hypermobility had a high prevalence of spinal curvature, these studies were at high risk of confounding. Wide variation in methods of measuring musculoskeletal hypermobility and the challenge of assessing AIS in population-based studies hinder study comparison. CONCLUSIONS: There is a paucity of high-quality evidence examining the association between isolated musculoskeletal hypermobility and AIS. Large-scale prospective studies with adequate adjustment for potential confounding factors could clarify the relationship between musculoskeletal hypermobility and AIS to elucidate its role in the pathogenesis of AIS.
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spelling pubmed-101921772023-05-19 Systematic review of the association between isolated musculoskeletal hypermobility and adolescent idiopathic scoliosis Shere, Clare Clark, Emma M. Arch Orthop Trauma Surg Orthopaedic Surgery INTRODUCTION: Adolescent idiopathic scoliosis (AIS) affects 1–3% of the population, but its pathogenesis remains unclear. The coexistence of musculoskeletal hypermobility and scoliosis in many inherited syndromes raises the possibility that isolated musculoskeletal hypermobility may contribute to AIS development or progression. METHODS: We performed a systematic review of the evidence for a relationship between isolated musculoskeletal hypermobility and AIS. A meta-analysis was planned, but if not possible, a narrative evidence synthesis was planned. RESULTS: Nineteen studies met eligibility criteria for inclusion. One study was excluded due to insufficient quality. Substantial heterogeneity in study design and methodology negated meta-analysis, so a narrative review was performed. Of the 18 studies included, seven suggested a positive association and eight found no association. Three reported the prevalence of musculoskeletal hypermobility in individuals with AIS. Overall, there was no convincing population-based evidence for an association between musculoskeletal hypermobility and AIS, with only two case–control studies by the same authors presenting compelling evidence for an association. Although populations at extremes of hypermobility had a high prevalence of spinal curvature, these studies were at high risk of confounding. Wide variation in methods of measuring musculoskeletal hypermobility and the challenge of assessing AIS in population-based studies hinder study comparison. CONCLUSIONS: There is a paucity of high-quality evidence examining the association between isolated musculoskeletal hypermobility and AIS. Large-scale prospective studies with adequate adjustment for potential confounding factors could clarify the relationship between musculoskeletal hypermobility and AIS to elucidate its role in the pathogenesis of AIS. Springer Berlin Heidelberg 2022-07-16 2023 /pmc/articles/PMC10192177/ /pubmed/35841409 http://dx.doi.org/10.1007/s00402-022-04508-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Orthopaedic Surgery
Shere, Clare
Clark, Emma M.
Systematic review of the association between isolated musculoskeletal hypermobility and adolescent idiopathic scoliosis
title Systematic review of the association between isolated musculoskeletal hypermobility and adolescent idiopathic scoliosis
title_full Systematic review of the association between isolated musculoskeletal hypermobility and adolescent idiopathic scoliosis
title_fullStr Systematic review of the association between isolated musculoskeletal hypermobility and adolescent idiopathic scoliosis
title_full_unstemmed Systematic review of the association between isolated musculoskeletal hypermobility and adolescent idiopathic scoliosis
title_short Systematic review of the association between isolated musculoskeletal hypermobility and adolescent idiopathic scoliosis
title_sort systematic review of the association between isolated musculoskeletal hypermobility and adolescent idiopathic scoliosis
topic Orthopaedic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192177/
https://www.ncbi.nlm.nih.gov/pubmed/35841409
http://dx.doi.org/10.1007/s00402-022-04508-z
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