Cargando…
General anesthesia with propofol during oocyte retrieval and in vitro fertilization outcomes: retrospective cohort study
General anesthesia is frequently administered during oocyte retrieval. Its effects on the outcomes of IVF cycles are uncertain. This study investigated whether administration of general anesthesia (specifically propofol) during oocyte retrieval affects IVF outcomes. A total of 245 women undergoing I...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192324/ https://www.ncbi.nlm.nih.gov/pubmed/37198399 http://dx.doi.org/10.1038/s41598-023-35224-2 |
_version_ | 1785043604469710848 |
---|---|
author | Haikin Herzberger, Einat Levy, Omri Sun, Bei Miller, Netanella Rahav, Roni Dana, Elad Raviv, Shaul Hershko-Klement, Anat Wiser, Amir |
author_facet | Haikin Herzberger, Einat Levy, Omri Sun, Bei Miller, Netanella Rahav, Roni Dana, Elad Raviv, Shaul Hershko-Klement, Anat Wiser, Amir |
author_sort | Haikin Herzberger, Einat |
collection | PubMed |
description | General anesthesia is frequently administered during oocyte retrieval. Its effects on the outcomes of IVF cycles are uncertain. This study investigated whether administration of general anesthesia (specifically propofol) during oocyte retrieval affects IVF outcomes. A total of 245 women undergoing IVF cycles were included in this retrospective cohort study. IVF outcomes of 129 women who underwent oocyte retrieval under propofol anesthesia and 116 without anesthesia were compared. Data were adjusted for age, BMI, estradiol on triggering day and total gonadotropin dose. The primary outcomes were fertilization, pregnancy and live birth rates. A secondary outcome was the efficiency of follicle retrieval associated with the use of anesthesia. Fertilization rate was lower in retrievals under anesthesia compared to without (53.4% ± 34.8 vs. 63.7% ± 33.6, respectively; p = 0.02). There was no significant difference in the ratio of expected to retrieved oocytes between retrievals with and without anesthesia (0.8 ± 0.4 vs. 0.8 ± 0.8, respectively, p = 0.96). The differences in pregnancy and live birth rates between the groups were not statistically significant. General anesthesia administered during oocyte retrieval may have adverse effects on the fertilization potential of oocytes. This impact on the developmental potential of oocytes may lead to negative IVF outcomes and should be investigated further. |
format | Online Article Text |
id | pubmed-10192324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-101923242023-05-19 General anesthesia with propofol during oocyte retrieval and in vitro fertilization outcomes: retrospective cohort study Haikin Herzberger, Einat Levy, Omri Sun, Bei Miller, Netanella Rahav, Roni Dana, Elad Raviv, Shaul Hershko-Klement, Anat Wiser, Amir Sci Rep Article General anesthesia is frequently administered during oocyte retrieval. Its effects on the outcomes of IVF cycles are uncertain. This study investigated whether administration of general anesthesia (specifically propofol) during oocyte retrieval affects IVF outcomes. A total of 245 women undergoing IVF cycles were included in this retrospective cohort study. IVF outcomes of 129 women who underwent oocyte retrieval under propofol anesthesia and 116 without anesthesia were compared. Data were adjusted for age, BMI, estradiol on triggering day and total gonadotropin dose. The primary outcomes were fertilization, pregnancy and live birth rates. A secondary outcome was the efficiency of follicle retrieval associated with the use of anesthesia. Fertilization rate was lower in retrievals under anesthesia compared to without (53.4% ± 34.8 vs. 63.7% ± 33.6, respectively; p = 0.02). There was no significant difference in the ratio of expected to retrieved oocytes between retrievals with and without anesthesia (0.8 ± 0.4 vs. 0.8 ± 0.8, respectively, p = 0.96). The differences in pregnancy and live birth rates between the groups were not statistically significant. General anesthesia administered during oocyte retrieval may have adverse effects on the fertilization potential of oocytes. This impact on the developmental potential of oocytes may lead to negative IVF outcomes and should be investigated further. Nature Publishing Group UK 2023-05-17 /pmc/articles/PMC10192324/ /pubmed/37198399 http://dx.doi.org/10.1038/s41598-023-35224-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Haikin Herzberger, Einat Levy, Omri Sun, Bei Miller, Netanella Rahav, Roni Dana, Elad Raviv, Shaul Hershko-Klement, Anat Wiser, Amir General anesthesia with propofol during oocyte retrieval and in vitro fertilization outcomes: retrospective cohort study |
title | General anesthesia with propofol during oocyte retrieval and in vitro fertilization outcomes: retrospective cohort study |
title_full | General anesthesia with propofol during oocyte retrieval and in vitro fertilization outcomes: retrospective cohort study |
title_fullStr | General anesthesia with propofol during oocyte retrieval and in vitro fertilization outcomes: retrospective cohort study |
title_full_unstemmed | General anesthesia with propofol during oocyte retrieval and in vitro fertilization outcomes: retrospective cohort study |
title_short | General anesthesia with propofol during oocyte retrieval and in vitro fertilization outcomes: retrospective cohort study |
title_sort | general anesthesia with propofol during oocyte retrieval and in vitro fertilization outcomes: retrospective cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192324/ https://www.ncbi.nlm.nih.gov/pubmed/37198399 http://dx.doi.org/10.1038/s41598-023-35224-2 |
work_keys_str_mv | AT haikinherzbergereinat generalanesthesiawithpropofolduringoocyteretrievalandinvitrofertilizationoutcomesretrospectivecohortstudy AT levyomri generalanesthesiawithpropofolduringoocyteretrievalandinvitrofertilizationoutcomesretrospectivecohortstudy AT sunbei generalanesthesiawithpropofolduringoocyteretrievalandinvitrofertilizationoutcomesretrospectivecohortstudy AT millernetanella generalanesthesiawithpropofolduringoocyteretrievalandinvitrofertilizationoutcomesretrospectivecohortstudy AT rahavroni generalanesthesiawithpropofolduringoocyteretrievalandinvitrofertilizationoutcomesretrospectivecohortstudy AT danaelad generalanesthesiawithpropofolduringoocyteretrievalandinvitrofertilizationoutcomesretrospectivecohortstudy AT ravivshaul generalanesthesiawithpropofolduringoocyteretrievalandinvitrofertilizationoutcomesretrospectivecohortstudy AT hershkoklementanat generalanesthesiawithpropofolduringoocyteretrievalandinvitrofertilizationoutcomesretrospectivecohortstudy AT wiseramir generalanesthesiawithpropofolduringoocyteretrievalandinvitrofertilizationoutcomesretrospectivecohortstudy |