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Underweight and risk of fractures in adults over 40 years using the nationwide claims database

We aimed to investigate how underweight affects the incidence of fractures, as well as the influence of cumulative, longitudinal periods of low body mass index (BMI) and changes in body weight on fracture development. Data on adults aged 40-year and over who had three health screenings between Janua...

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Autores principales: Park, Sang-Min, Park, Jiwon, Han, Sangsoo, Jang, Hae-Dong, Hong, Jae-Young, Han, Kyungdo, Kim, Ho-Joong, Yeom, Jin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192329/
https://www.ncbi.nlm.nih.gov/pubmed/37198201
http://dx.doi.org/10.1038/s41598-023-34828-y
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author Park, Sang-Min
Park, Jiwon
Han, Sangsoo
Jang, Hae-Dong
Hong, Jae-Young
Han, Kyungdo
Kim, Ho-Joong
Yeom, Jin S.
author_facet Park, Sang-Min
Park, Jiwon
Han, Sangsoo
Jang, Hae-Dong
Hong, Jae-Young
Han, Kyungdo
Kim, Ho-Joong
Yeom, Jin S.
author_sort Park, Sang-Min
collection PubMed
description We aimed to investigate how underweight affects the incidence of fractures, as well as the influence of cumulative, longitudinal periods of low body mass index (BMI) and changes in body weight on fracture development. Data on adults aged 40-year and over who had three health screenings between January 1, 2007, and December 31, 2009 were used to determine the incidence of new fractures. The hazard ratios (HRs) for new fractures depending on BMI, total cumulative number of underweight, and weight change over time were calculated using Cox proportional hazard analysis. In this study, 15,955 (2.8%) of the 561,779 adults were diagnosed with fractures more than once over three health examinations. The fully adjusted HR for fractures in underweight individuals was 1.173 (95% Confidence interval [CI] 1.093–1.259). Underweight individuals diagnosed only once, twice, or three times had an adjusted HR of 1.227 (95%CI 1.130–1.332), 1.174 (95%CI 1.045–1.319), and 1.255 (95%CI 1.143–1.379), respectively. Although the adjusted HR was higher in adults who consistently had underweight (HR; 1.250 [95%CI 1.146–1.363]), those with underweight had an increased risk of fractures regardless of weight change (HR; 1.171 [95%CI 1.045–1.312], and 1.203[95%CI 1.075–1.346]). Underweight is a risk factor for fractures in adults over the age of 40 years, even if they returned to normal weight.
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spelling pubmed-101923292023-05-19 Underweight and risk of fractures in adults over 40 years using the nationwide claims database Park, Sang-Min Park, Jiwon Han, Sangsoo Jang, Hae-Dong Hong, Jae-Young Han, Kyungdo Kim, Ho-Joong Yeom, Jin S. Sci Rep Article We aimed to investigate how underweight affects the incidence of fractures, as well as the influence of cumulative, longitudinal periods of low body mass index (BMI) and changes in body weight on fracture development. Data on adults aged 40-year and over who had three health screenings between January 1, 2007, and December 31, 2009 were used to determine the incidence of new fractures. The hazard ratios (HRs) for new fractures depending on BMI, total cumulative number of underweight, and weight change over time were calculated using Cox proportional hazard analysis. In this study, 15,955 (2.8%) of the 561,779 adults were diagnosed with fractures more than once over three health examinations. The fully adjusted HR for fractures in underweight individuals was 1.173 (95% Confidence interval [CI] 1.093–1.259). Underweight individuals diagnosed only once, twice, or three times had an adjusted HR of 1.227 (95%CI 1.130–1.332), 1.174 (95%CI 1.045–1.319), and 1.255 (95%CI 1.143–1.379), respectively. Although the adjusted HR was higher in adults who consistently had underweight (HR; 1.250 [95%CI 1.146–1.363]), those with underweight had an increased risk of fractures regardless of weight change (HR; 1.171 [95%CI 1.045–1.312], and 1.203[95%CI 1.075–1.346]). Underweight is a risk factor for fractures in adults over the age of 40 years, even if they returned to normal weight. Nature Publishing Group UK 2023-05-17 /pmc/articles/PMC10192329/ /pubmed/37198201 http://dx.doi.org/10.1038/s41598-023-34828-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Park, Sang-Min
Park, Jiwon
Han, Sangsoo
Jang, Hae-Dong
Hong, Jae-Young
Han, Kyungdo
Kim, Ho-Joong
Yeom, Jin S.
Underweight and risk of fractures in adults over 40 years using the nationwide claims database
title Underweight and risk of fractures in adults over 40 years using the nationwide claims database
title_full Underweight and risk of fractures in adults over 40 years using the nationwide claims database
title_fullStr Underweight and risk of fractures in adults over 40 years using the nationwide claims database
title_full_unstemmed Underweight and risk of fractures in adults over 40 years using the nationwide claims database
title_short Underweight and risk of fractures in adults over 40 years using the nationwide claims database
title_sort underweight and risk of fractures in adults over 40 years using the nationwide claims database
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192329/
https://www.ncbi.nlm.nih.gov/pubmed/37198201
http://dx.doi.org/10.1038/s41598-023-34828-y
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