A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...

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Detalles Bibliográficos
Autores principales: Chinnapaiyan, Srinivasan, Santiago, Maria-Jose, Panda, Kingshuk, Rahman, Md. Sohanur, Alluin, Jessica, Rossi, John, Unwalla, Hoshang J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192333/
https://www.ncbi.nlm.nih.gov/pubmed/37215150
http://dx.doi.org/10.1016/j.omtn.2023.04.011

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