Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis

Microglia play a role in the pathogenesis of many retinal diseases. Fundus spots in mice often correlate with the accumulation of activated subretinal microglia. Here we use a semiquantitative fundus spot scoring scale in combination with an unbiased, state-of-the-science forward genetics pipeline t...

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Detalles Bibliográficos
Autores principales: Yuksel, Seher, Aredo, Bogale, Zegeye, Yeshumenesh, Zhao, Cynthia X., Tang, Miao, Li, Xiaohong, Hulleman, John D., Gautron, Laurent, Ludwig, Sara, Moresco, Eva M. Y., Butovich, Igor A., Beutler, Bruce A., Ufret-Vincenty, Rafael L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192353/
https://www.ncbi.nlm.nih.gov/pubmed/37198396
http://dx.doi.org/10.1038/s42003-023-04870-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192353/
https://www.ncbi.nlm.nih.gov/pubmed/37198396
http://dx.doi.org/10.1038/s42003-023-04870-7

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