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Recent advances and new perspectives in mitochondrial dysfunction
In the last decade, there has been an increased appreciation for mitochondria as central hubs in diverse processes, such as cellular energy, immunity, and signal transduction. As such, we have become aware that mitochondrial dysfunction underlies many diseases, including primary (mutations in genes...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192368/ https://www.ncbi.nlm.nih.gov/pubmed/37198256 http://dx.doi.org/10.1038/s41598-023-34624-8 |
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author | Giulivi, Cecilia Zhang, Kezhong Arakawa, Hirofumi |
author_facet | Giulivi, Cecilia Zhang, Kezhong Arakawa, Hirofumi |
author_sort | Giulivi, Cecilia |
collection | PubMed |
description | In the last decade, there has been an increased appreciation for mitochondria as central hubs in diverse processes, such as cellular energy, immunity, and signal transduction. As such, we have become aware that mitochondrial dysfunction underlies many diseases, including primary (mutations in genes encoding mitochondrial proteins) and secondary mitochondrial diseases (mutations in non-mitochondrial genes critical for mitochondrial biology), as well as complex diseases with mitochondrial dysfunction (chronic or degenerative diseases). Evidence suggests that mitochondrial dysfunction may often precede other pathological signs in these disorders, further modulated by genetics, environment, and lifestyle. |
format | Online Article Text |
id | pubmed-10192368 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-101923682023-05-19 Recent advances and new perspectives in mitochondrial dysfunction Giulivi, Cecilia Zhang, Kezhong Arakawa, Hirofumi Sci Rep Editorial In the last decade, there has been an increased appreciation for mitochondria as central hubs in diverse processes, such as cellular energy, immunity, and signal transduction. As such, we have become aware that mitochondrial dysfunction underlies many diseases, including primary (mutations in genes encoding mitochondrial proteins) and secondary mitochondrial diseases (mutations in non-mitochondrial genes critical for mitochondrial biology), as well as complex diseases with mitochondrial dysfunction (chronic or degenerative diseases). Evidence suggests that mitochondrial dysfunction may often precede other pathological signs in these disorders, further modulated by genetics, environment, and lifestyle. Nature Publishing Group UK 2023-05-17 /pmc/articles/PMC10192368/ /pubmed/37198256 http://dx.doi.org/10.1038/s41598-023-34624-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Editorial Giulivi, Cecilia Zhang, Kezhong Arakawa, Hirofumi Recent advances and new perspectives in mitochondrial dysfunction |
title | Recent advances and new perspectives in mitochondrial dysfunction |
title_full | Recent advances and new perspectives in mitochondrial dysfunction |
title_fullStr | Recent advances and new perspectives in mitochondrial dysfunction |
title_full_unstemmed | Recent advances and new perspectives in mitochondrial dysfunction |
title_short | Recent advances and new perspectives in mitochondrial dysfunction |
title_sort | recent advances and new perspectives in mitochondrial dysfunction |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192368/ https://www.ncbi.nlm.nih.gov/pubmed/37198256 http://dx.doi.org/10.1038/s41598-023-34624-8 |
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