ABRAXAS1 orchestrates BRCA1 activities to counter genome destabilizing repair pathways—lessons from breast cancer patients

It has been well-established that mutations in BRCA1 and BRCA2, compromising functions in DNA double-strand break repair (DSBR), confer hereditary breast and ovarian cancer risk. Importantly, mutations in these genes explain only a minor fraction of the hereditary risk and of the subset of DSBR defi...

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Detalles Bibliográficos
Autores principales: Sachsenweger, Juliane, Jansche, Rebecca, Merk, Tatjana, Heitmeir, Benedikt, Deniz, Miriam, Faust, Ulrike, Roggia, Cristiana, Tzschach, Andreas, Schroeder, Christopher, Riess, Angelika, Pospiech, Helmut, Peltoketo, Hellevi, Pylkäs, Katri, Winqvist, Robert, Wiesmüller, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192442/
https://www.ncbi.nlm.nih.gov/pubmed/37198153
http://dx.doi.org/10.1038/s41419-023-05845-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192442/
https://www.ncbi.nlm.nih.gov/pubmed/37198153
http://dx.doi.org/10.1038/s41419-023-05845-6

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