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Thigh muscle metabolic response is linked to feed efficiency and meat characteristics in slow-growing chicken

The Korat chicken (KR) is a slow-growing Thai chicken breed with relatively poor feed efficiency (FE) but very tasty meat with high protein and low fat contents, and a unique texture. To enhance the competitiveness of KR, its FE should be improved. However, selecting for FE has an unknown effect on...

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Autores principales: Kaewsatuan, Pramin, Poompramun, Chotima, Kubota, Satoshi, Yongsawatdigul, Jirawat, Molee, Wittawat, Uimari, Pekka, Molee, Amonrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192536/
https://www.ncbi.nlm.nih.gov/pubmed/37186966
http://dx.doi.org/10.1016/j.psj.2023.102741
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author Kaewsatuan, Pramin
Poompramun, Chotima
Kubota, Satoshi
Yongsawatdigul, Jirawat
Molee, Wittawat
Uimari, Pekka
Molee, Amonrat
author_facet Kaewsatuan, Pramin
Poompramun, Chotima
Kubota, Satoshi
Yongsawatdigul, Jirawat
Molee, Wittawat
Uimari, Pekka
Molee, Amonrat
author_sort Kaewsatuan, Pramin
collection PubMed
description The Korat chicken (KR) is a slow-growing Thai chicken breed with relatively poor feed efficiency (FE) but very tasty meat with high protein and low fat contents, and a unique texture. To enhance the competitiveness of KR, its FE should be improved. However, selecting for FE has an unknown effect on meat characteristics. Thus, understanding the genetic basis underlying FE traits and meat characteristics is needed. In this study, 75 male KR birds were raised up to 10 wk of age. For each bird, the feed conversion ratio (FCR), residual feed intake (RFI), and physicochemical properties, flavor precursors, and biological compounds in the thigh meat were evaluated. At 10 wk of age, thigh muscle samples from 6 birds (3 with high FCR and 3 with low FCR values) were selected, and their proteomes were investigated using a label-free proteomic method. Weighted gene coexpression network analysis (WGCNA) was used to screen the key protein modules and pathways. The WGCNA results revealed that FE and meat characteristics significantly correlated with the same protein module. However, the correlation was unfavorable; improving FE may result in a decrease in meat quality through the alteration in biological processes including glycolysis/gluconeogenesis, metabolic pathway, carbon metabolism, biosynthesis of amino acids, pyruvate metabolism, and protein processing in the endoplasmic reticulum. The hub proteins of the significant module (TNNT1, TNNT3, TNNI2, TNNC2, MYLPF, MYH10, GADPH, PGK1, LDHA, and GPI) were also identified to be associated with energy metabolism, and muscle growth and development. Given that the same proteins and pathways are present in FE and meat characteristics but in opposite directions, selection practices for KR should simultaneously consider both trait groups to maintain the high meat quality of KR while improving FE.
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spelling pubmed-101925362023-05-19 Thigh muscle metabolic response is linked to feed efficiency and meat characteristics in slow-growing chicken Kaewsatuan, Pramin Poompramun, Chotima Kubota, Satoshi Yongsawatdigul, Jirawat Molee, Wittawat Uimari, Pekka Molee, Amonrat Poult Sci GENETICS AND MOLECULAR BIOLOGY The Korat chicken (KR) is a slow-growing Thai chicken breed with relatively poor feed efficiency (FE) but very tasty meat with high protein and low fat contents, and a unique texture. To enhance the competitiveness of KR, its FE should be improved. However, selecting for FE has an unknown effect on meat characteristics. Thus, understanding the genetic basis underlying FE traits and meat characteristics is needed. In this study, 75 male KR birds were raised up to 10 wk of age. For each bird, the feed conversion ratio (FCR), residual feed intake (RFI), and physicochemical properties, flavor precursors, and biological compounds in the thigh meat were evaluated. At 10 wk of age, thigh muscle samples from 6 birds (3 with high FCR and 3 with low FCR values) were selected, and their proteomes were investigated using a label-free proteomic method. Weighted gene coexpression network analysis (WGCNA) was used to screen the key protein modules and pathways. The WGCNA results revealed that FE and meat characteristics significantly correlated with the same protein module. However, the correlation was unfavorable; improving FE may result in a decrease in meat quality through the alteration in biological processes including glycolysis/gluconeogenesis, metabolic pathway, carbon metabolism, biosynthesis of amino acids, pyruvate metabolism, and protein processing in the endoplasmic reticulum. The hub proteins of the significant module (TNNT1, TNNT3, TNNI2, TNNC2, MYLPF, MYH10, GADPH, PGK1, LDHA, and GPI) were also identified to be associated with energy metabolism, and muscle growth and development. Given that the same proteins and pathways are present in FE and meat characteristics but in opposite directions, selection practices for KR should simultaneously consider both trait groups to maintain the high meat quality of KR while improving FE. Elsevier 2023-04-23 /pmc/articles/PMC10192536/ /pubmed/37186966 http://dx.doi.org/10.1016/j.psj.2023.102741 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle GENETICS AND MOLECULAR BIOLOGY
Kaewsatuan, Pramin
Poompramun, Chotima
Kubota, Satoshi
Yongsawatdigul, Jirawat
Molee, Wittawat
Uimari, Pekka
Molee, Amonrat
Thigh muscle metabolic response is linked to feed efficiency and meat characteristics in slow-growing chicken
title Thigh muscle metabolic response is linked to feed efficiency and meat characteristics in slow-growing chicken
title_full Thigh muscle metabolic response is linked to feed efficiency and meat characteristics in slow-growing chicken
title_fullStr Thigh muscle metabolic response is linked to feed efficiency and meat characteristics in slow-growing chicken
title_full_unstemmed Thigh muscle metabolic response is linked to feed efficiency and meat characteristics in slow-growing chicken
title_short Thigh muscle metabolic response is linked to feed efficiency and meat characteristics in slow-growing chicken
title_sort thigh muscle metabolic response is linked to feed efficiency and meat characteristics in slow-growing chicken
topic GENETICS AND MOLECULAR BIOLOGY
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192536/
https://www.ncbi.nlm.nih.gov/pubmed/37186966
http://dx.doi.org/10.1016/j.psj.2023.102741
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