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The mechanisms and diagnostic potential of lncRNAs, miRNAs, and their related signaling pathways in cervical cancer

Cervical cancer (CC), the fourth most prevalent type of cancer among women worldwide, is associated with high rates of morbidity and mortality. Due to the long period of latency in CC, most patients are already in the middle to late stages when initially diagnosed, which greatly reduces the clinical...

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Autores principales: Xu, Yan, Sun, Yu, Song, Xiaobin, Ren, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192553/
https://www.ncbi.nlm.nih.gov/pubmed/37215076
http://dx.doi.org/10.3389/fcell.2023.1170059
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author Xu, Yan
Sun, Yu
Song, Xiaobin
Ren, Jian
author_facet Xu, Yan
Sun, Yu
Song, Xiaobin
Ren, Jian
author_sort Xu, Yan
collection PubMed
description Cervical cancer (CC), the fourth most prevalent type of cancer among women worldwide, is associated with high rates of morbidity and mortality. Due to the long period of latency in CC, most patients are already in the middle to late stages when initially diagnosed, which greatly reduces the clinical cure rate and quality of survival, thus resulting in poor outcomes. In recent years, with continuous exploration in the fields of bioinformatics and molecules, it has been found that ncRNAs, including miRNAs and lncRNAs, without the ability to translate proteins are capable of activating or inhibiting certain signaling pathways by targeting and modulating the level of expression of proteins involved in these signaling pathways. ncRNAs play important roles in assisting with diagnosis, drug administration, and prediction of prognosis during CC progression. As an entry point, the mechanisms of interaction between miRNAs, lncRNAs, and signaling pathways have long been a focus in basic research relating to CC, and numerous experimental studies have confirmed the close relationship of miRNAs, lncRNAs, and signaling pathways with CC development. Against this background, we summarize the latest advances in the involvement of lncRNA- and miRNA-related signaling pathways in the development of CC to provide guidance for CC treatment.
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spelling pubmed-101925532023-05-19 The mechanisms and diagnostic potential of lncRNAs, miRNAs, and their related signaling pathways in cervical cancer Xu, Yan Sun, Yu Song, Xiaobin Ren, Jian Front Cell Dev Biol Cell and Developmental Biology Cervical cancer (CC), the fourth most prevalent type of cancer among women worldwide, is associated with high rates of morbidity and mortality. Due to the long period of latency in CC, most patients are already in the middle to late stages when initially diagnosed, which greatly reduces the clinical cure rate and quality of survival, thus resulting in poor outcomes. In recent years, with continuous exploration in the fields of bioinformatics and molecules, it has been found that ncRNAs, including miRNAs and lncRNAs, without the ability to translate proteins are capable of activating or inhibiting certain signaling pathways by targeting and modulating the level of expression of proteins involved in these signaling pathways. ncRNAs play important roles in assisting with diagnosis, drug administration, and prediction of prognosis during CC progression. As an entry point, the mechanisms of interaction between miRNAs, lncRNAs, and signaling pathways have long been a focus in basic research relating to CC, and numerous experimental studies have confirmed the close relationship of miRNAs, lncRNAs, and signaling pathways with CC development. Against this background, we summarize the latest advances in the involvement of lncRNA- and miRNA-related signaling pathways in the development of CC to provide guidance for CC treatment. Frontiers Media S.A. 2023-05-04 /pmc/articles/PMC10192553/ /pubmed/37215076 http://dx.doi.org/10.3389/fcell.2023.1170059 Text en Copyright © 2023 Xu, Sun, Song and Ren. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Xu, Yan
Sun, Yu
Song, Xiaobin
Ren, Jian
The mechanisms and diagnostic potential of lncRNAs, miRNAs, and their related signaling pathways in cervical cancer
title The mechanisms and diagnostic potential of lncRNAs, miRNAs, and their related signaling pathways in cervical cancer
title_full The mechanisms and diagnostic potential of lncRNAs, miRNAs, and their related signaling pathways in cervical cancer
title_fullStr The mechanisms and diagnostic potential of lncRNAs, miRNAs, and their related signaling pathways in cervical cancer
title_full_unstemmed The mechanisms and diagnostic potential of lncRNAs, miRNAs, and their related signaling pathways in cervical cancer
title_short The mechanisms and diagnostic potential of lncRNAs, miRNAs, and their related signaling pathways in cervical cancer
title_sort mechanisms and diagnostic potential of lncrnas, mirnas, and their related signaling pathways in cervical cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192553/
https://www.ncbi.nlm.nih.gov/pubmed/37215076
http://dx.doi.org/10.3389/fcell.2023.1170059
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