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Progressive multifocal leukoencephalopathy in a patient with multiple myeloma: a case report and analysis of the FDA adverse event reporting system

This paper demonstrates a case of progressive multifocal leukoencephalopathy (PML) in a patient with multiple myeloma (MM) treated with nine different MM therapies. This case report contributes to the already published 16 cases of PML in patients with MM. Additionally, this paper presents an analysi...

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Autores principales: Jonasson, Elise, Antulov, Ronald, Trøllund Pedersen, Per, Sejbæk, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192558/
https://www.ncbi.nlm.nih.gov/pubmed/37213905
http://dx.doi.org/10.3389/fneur.2023.1098930
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author Jonasson, Elise
Antulov, Ronald
Trøllund Pedersen, Per
Sejbæk, Tobias
author_facet Jonasson, Elise
Antulov, Ronald
Trøllund Pedersen, Per
Sejbæk, Tobias
author_sort Jonasson, Elise
collection PubMed
description This paper demonstrates a case of progressive multifocal leukoencephalopathy (PML) in a patient with multiple myeloma (MM) treated with nine different MM therapies. This case report contributes to the already published 16 cases of PML in patients with MM. Additionally, this paper presents an analysis of cases from the United States Food and Drug Administration Adverse Event Report System database (n = 117) with a description of demographics and MM-specific therapies. Patients with MM, that developed PML, were treated with immunomodulatory drugs (97%), alkylating agents (52%), and/or proteasome inhibitors (49%). Prior to PML diagnosis, 72% of patients received two or more MM therapies. These results indicate that PML in MM is underreported and could be related to treatment with multiple immunosuppressive therapies rather than MM as a disease itself. Physicians should be aware of potential PML in the late stage of heavily treated MM patients.
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spelling pubmed-101925582023-05-19 Progressive multifocal leukoencephalopathy in a patient with multiple myeloma: a case report and analysis of the FDA adverse event reporting system Jonasson, Elise Antulov, Ronald Trøllund Pedersen, Per Sejbæk, Tobias Front Neurol Neurology This paper demonstrates a case of progressive multifocal leukoencephalopathy (PML) in a patient with multiple myeloma (MM) treated with nine different MM therapies. This case report contributes to the already published 16 cases of PML in patients with MM. Additionally, this paper presents an analysis of cases from the United States Food and Drug Administration Adverse Event Report System database (n = 117) with a description of demographics and MM-specific therapies. Patients with MM, that developed PML, were treated with immunomodulatory drugs (97%), alkylating agents (52%), and/or proteasome inhibitors (49%). Prior to PML diagnosis, 72% of patients received two or more MM therapies. These results indicate that PML in MM is underreported and could be related to treatment with multiple immunosuppressive therapies rather than MM as a disease itself. Physicians should be aware of potential PML in the late stage of heavily treated MM patients. Frontiers Media S.A. 2023-05-04 /pmc/articles/PMC10192558/ /pubmed/37213905 http://dx.doi.org/10.3389/fneur.2023.1098930 Text en Copyright © 2023 Jonasson, Antulov, Trøllund Pedersen and Sejbæk. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Jonasson, Elise
Antulov, Ronald
Trøllund Pedersen, Per
Sejbæk, Tobias
Progressive multifocal leukoencephalopathy in a patient with multiple myeloma: a case report and analysis of the FDA adverse event reporting system
title Progressive multifocal leukoencephalopathy in a patient with multiple myeloma: a case report and analysis of the FDA adverse event reporting system
title_full Progressive multifocal leukoencephalopathy in a patient with multiple myeloma: a case report and analysis of the FDA adverse event reporting system
title_fullStr Progressive multifocal leukoencephalopathy in a patient with multiple myeloma: a case report and analysis of the FDA adverse event reporting system
title_full_unstemmed Progressive multifocal leukoencephalopathy in a patient with multiple myeloma: a case report and analysis of the FDA adverse event reporting system
title_short Progressive multifocal leukoencephalopathy in a patient with multiple myeloma: a case report and analysis of the FDA adverse event reporting system
title_sort progressive multifocal leukoencephalopathy in a patient with multiple myeloma: a case report and analysis of the fda adverse event reporting system
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192558/
https://www.ncbi.nlm.nih.gov/pubmed/37213905
http://dx.doi.org/10.3389/fneur.2023.1098930
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