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The combined associations of depression and cognitive impairment with functional disability and mortality in older adults: a population-based study from the NHANES 2011–2014
OBJECTIVE: The present study aimed to explore the combined associations of depression and cognitive impairment with functional disability and mortality, and whether the joint effects of depression and cognitive impairment on mortality were influenced by functional disability. METHODS: A total of 2,3...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192607/ https://www.ncbi.nlm.nih.gov/pubmed/37213544 http://dx.doi.org/10.3389/fnagi.2023.1121190 |
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author | Han, Shuang Gao, Yue Gan, Da |
author_facet | Han, Shuang Gao, Yue Gan, Da |
author_sort | Han, Shuang |
collection | PubMed |
description | OBJECTIVE: The present study aimed to explore the combined associations of depression and cognitive impairment with functional disability and mortality, and whether the joint effects of depression and cognitive impairment on mortality were influenced by functional disability. METHODS: A total of 2,345 participants aged 60 and above from the 2011–2014 cycle of the National Health and Nutrition Examination Survey (NHANES) were included in the analyses. Questionnaires were used to evaluated depression, global cognitive function and functional disability (including disability in activities of daily living (ADLs), instrumental activities of daily living (IADLs), leisure and social activities (LSA), lower extremity mobility (LEM), and general physical activity (GPA)). Mortality status was ascertained up to December 31, 2019. Multivariable logistic regression was performed to investigate the associations of depression and low global cognition with functional disability. Cox proportional hazards regression models were conducted to evaluate the effect of depression and low global cognition on mortality. RESULTS: Interactions between depression and low global cognition were observed when exploring associations of depression and low global cognition with IADLs disability, LEM disability, and cardiovascular mortality. Compared with normal participants, participants with both depression and low global cognition had the highest odds ratios of disability in ADLs, IADLs, LSA, LEM, and GPA. Besides, participants with both depression and low global cognition also had the highest hazard ratios of all-cause mortality and cardiovascular mortality, and these associations remained after adjusting for disability in ADLs, IADLs, LSA, LEM, and GPA. CONCLUSION: Older adults with both depression and low global cognition were more likely to have functional disability, and had the highest risk of all-cause mortality and cardiovascular mortality. |
format | Online Article Text |
id | pubmed-10192607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101926072023-05-19 The combined associations of depression and cognitive impairment with functional disability and mortality in older adults: a population-based study from the NHANES 2011–2014 Han, Shuang Gao, Yue Gan, Da Front Aging Neurosci Aging Neuroscience OBJECTIVE: The present study aimed to explore the combined associations of depression and cognitive impairment with functional disability and mortality, and whether the joint effects of depression and cognitive impairment on mortality were influenced by functional disability. METHODS: A total of 2,345 participants aged 60 and above from the 2011–2014 cycle of the National Health and Nutrition Examination Survey (NHANES) were included in the analyses. Questionnaires were used to evaluated depression, global cognitive function and functional disability (including disability in activities of daily living (ADLs), instrumental activities of daily living (IADLs), leisure and social activities (LSA), lower extremity mobility (LEM), and general physical activity (GPA)). Mortality status was ascertained up to December 31, 2019. Multivariable logistic regression was performed to investigate the associations of depression and low global cognition with functional disability. Cox proportional hazards regression models were conducted to evaluate the effect of depression and low global cognition on mortality. RESULTS: Interactions between depression and low global cognition were observed when exploring associations of depression and low global cognition with IADLs disability, LEM disability, and cardiovascular mortality. Compared with normal participants, participants with both depression and low global cognition had the highest odds ratios of disability in ADLs, IADLs, LSA, LEM, and GPA. Besides, participants with both depression and low global cognition also had the highest hazard ratios of all-cause mortality and cardiovascular mortality, and these associations remained after adjusting for disability in ADLs, IADLs, LSA, LEM, and GPA. CONCLUSION: Older adults with both depression and low global cognition were more likely to have functional disability, and had the highest risk of all-cause mortality and cardiovascular mortality. Frontiers Media S.A. 2023-05-04 /pmc/articles/PMC10192607/ /pubmed/37213544 http://dx.doi.org/10.3389/fnagi.2023.1121190 Text en Copyright © 2023 Han, Gao and Gan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Neuroscience Han, Shuang Gao, Yue Gan, Da The combined associations of depression and cognitive impairment with functional disability and mortality in older adults: a population-based study from the NHANES 2011–2014 |
title | The combined associations of depression and cognitive impairment with functional disability and mortality in older adults: a population-based study from the NHANES 2011–2014 |
title_full | The combined associations of depression and cognitive impairment with functional disability and mortality in older adults: a population-based study from the NHANES 2011–2014 |
title_fullStr | The combined associations of depression and cognitive impairment with functional disability and mortality in older adults: a population-based study from the NHANES 2011–2014 |
title_full_unstemmed | The combined associations of depression and cognitive impairment with functional disability and mortality in older adults: a population-based study from the NHANES 2011–2014 |
title_short | The combined associations of depression and cognitive impairment with functional disability and mortality in older adults: a population-based study from the NHANES 2011–2014 |
title_sort | combined associations of depression and cognitive impairment with functional disability and mortality in older adults: a population-based study from the nhanes 2011–2014 |
topic | Aging Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192607/ https://www.ncbi.nlm.nih.gov/pubmed/37213544 http://dx.doi.org/10.3389/fnagi.2023.1121190 |
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