Mitochondrial rewiring drives metabolic adaptation to NAD(H) shortage in triple negative breast cancer cells

Nicotinamide phosphoribosyltransferase (NAMPT) is a key metabolic enzyme in NAD(+) synthesis pathways and is found upregulated in several tumors, depicting NAD(H) lowering agents, like the NAMPT inhibitor FK866, as an appealing approach for anticancer therapy. Like other small molecules, FK866 trigg...

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Detalles Bibliográficos
Autores principales: Carreira, Agata Sofia Assuncao, Ravera, Silvia, Zucal, Chiara, Thongon, Natthakan, Irene, Caffa, Astigiano, Cecilia, Bertola, Nadia, Buongiorno, Arianna, Roccuzzo, Michela, Bisio, Alessandra, Pardini, Barbara, Nencioni, Alessio, Bruzzone, Santina, Provenzani, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192916/
https://www.ncbi.nlm.nih.gov/pubmed/37148658
http://dx.doi.org/10.1016/j.neo.2023.100903

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