Pancreas-derived DPP4 is not essential for glucose homeostasis under metabolic stress

Mice systemically lacking dipeptidyl peptidase-4 (DPP4) have improved islet health, glucoregulation, and reduced obesity with high-fat diet (HFD) feeding compared to wild-type mice. Some, but not all, of this improvement can be linked to the loss of DPP4 in endothelial cells (ECs), pointing to the c...

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Detalles Bibliográficos
Autores principales: Fadzeyeva, Evgenia, Locatelli, Cassandra A.A., Trzaskalski, Natasha A., Nguyen, My-Anh, Capozzi, Megan E., Vulesevic, Branka, Morrow, Nadya M., Ghorbani, Peyman, Hanson, Antonio A., Lorenzen-Schmidt, Ilka, Doyle, Mary-Anne, Seymour, Richard, Varin, Elodie M., Fullerton, Morgan D., Campbell, Jonathan E., Mulvihill, Erin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192926/
https://www.ncbi.nlm.nih.gov/pubmed/37216093
http://dx.doi.org/10.1016/j.isci.2023.106748

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