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The ubiquitin ligase HERC4 suppresses MafA transcriptional activity triggered by GSK3β in myeloma by atypical K63-linked polyubiquitination

MafA and c-Maf are close members of the Maf transcription factor family and indicators of poor prognosis of multiple myeloma (MM). Our previous study finds that the ubiquitin ligase HERC4 induces c-Maf degradation but stabilizes MafA, and the mechanism is elusive. In the present study, we find that...

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Detalles Bibliográficos
Autores principales:	Zhang, Zubin, Li, Mei, Lin, Peng, Ren, Ying, He, Yuanming, Wang, Siyu, Xu, Yujia, Cao, Biyin, Wang, Guanghui, Moran, Michael F., Mao, Xinliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192928/ https://www.ncbi.nlm.nih.gov/pubmed/37028761 http://dx.doi.org/10.1016/j.jbc.2023.104675

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