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Commonalities and differences in ECT-induced gray matter volume change between depression and schizophrenia

BACKGROUND: Electroconvulsive therapy (ECT) is one of the most effective treatments for depression and schizophrenia, particularly in urgent or treatment-resistant cases. After ECT, regional gray matter volume (GMV) increases have been repeatedly reported both in depression and schizophrenia. Howeve...

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Autores principales: Kawashima, Hirotsugu, Yamasaki, Shimpei, Kubota, Manabu, Hazama, Masaaki, Fushimi, Yasutaka, Miyata, Jun, Murai, Toshiya, Suwa, Taro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193002/
https://www.ncbi.nlm.nih.gov/pubmed/37150022
http://dx.doi.org/10.1016/j.nicl.2023.103429
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author Kawashima, Hirotsugu
Yamasaki, Shimpei
Kubota, Manabu
Hazama, Masaaki
Fushimi, Yasutaka
Miyata, Jun
Murai, Toshiya
Suwa, Taro
author_facet Kawashima, Hirotsugu
Yamasaki, Shimpei
Kubota, Manabu
Hazama, Masaaki
Fushimi, Yasutaka
Miyata, Jun
Murai, Toshiya
Suwa, Taro
author_sort Kawashima, Hirotsugu
collection PubMed
description BACKGROUND: Electroconvulsive therapy (ECT) is one of the most effective treatments for depression and schizophrenia, particularly in urgent or treatment-resistant cases. After ECT, regional gray matter volume (GMV) increases have been repeatedly reported both in depression and schizophrenia. However, the interpretation of these findings remains entangled because GMV changes do not necessarily correlate with treatment effects and may be influenced by the intervention itself. We hypothesized that the comparison of longitudinal magnetic resonance imaging data between the two diagnostic groups will provide clues to distinguish diagnosis-specific and transdiagnostic changes. METHOD: Twenty-nine Japanese participants, including 18 inpatients with major depressive disorder and 11 with schizophrenia, underwent longitudinal voxel-based morphometry before and after ECT. We investigated GMV changes common to both diagnostic groups and those specific to each group. Moreover, we also evaluated potential associations between GMV changes and clinical improvement for each group. RESULTS: In both diagnostic groups, GMV increased in widespread areas after ECT, sharing common regions including: anterior temporal cortex; medial frontal and anterior cingulate cortex; insula; and caudate nucleus. In addition, we found a schizophrenia-specific GMV increase in a region including the left pregenual anterior cingulate cortex, with volume increase significantly correlating with clinical improvement. CONCLUSIONS: Transdiagnostic volume changes may represent the effects of the intervention itself and pathophysiological changes common to both groups. Conversely, diagnosis-specific volume changes are associated with treatment effects and may represent pathophysiology-specific impacts of ECT.
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spelling pubmed-101930022023-05-19 Commonalities and differences in ECT-induced gray matter volume change between depression and schizophrenia Kawashima, Hirotsugu Yamasaki, Shimpei Kubota, Manabu Hazama, Masaaki Fushimi, Yasutaka Miyata, Jun Murai, Toshiya Suwa, Taro Neuroimage Clin Regular Article BACKGROUND: Electroconvulsive therapy (ECT) is one of the most effective treatments for depression and schizophrenia, particularly in urgent or treatment-resistant cases. After ECT, regional gray matter volume (GMV) increases have been repeatedly reported both in depression and schizophrenia. However, the interpretation of these findings remains entangled because GMV changes do not necessarily correlate with treatment effects and may be influenced by the intervention itself. We hypothesized that the comparison of longitudinal magnetic resonance imaging data between the two diagnostic groups will provide clues to distinguish diagnosis-specific and transdiagnostic changes. METHOD: Twenty-nine Japanese participants, including 18 inpatients with major depressive disorder and 11 with schizophrenia, underwent longitudinal voxel-based morphometry before and after ECT. We investigated GMV changes common to both diagnostic groups and those specific to each group. Moreover, we also evaluated potential associations between GMV changes and clinical improvement for each group. RESULTS: In both diagnostic groups, GMV increased in widespread areas after ECT, sharing common regions including: anterior temporal cortex; medial frontal and anterior cingulate cortex; insula; and caudate nucleus. In addition, we found a schizophrenia-specific GMV increase in a region including the left pregenual anterior cingulate cortex, with volume increase significantly correlating with clinical improvement. CONCLUSIONS: Transdiagnostic volume changes may represent the effects of the intervention itself and pathophysiological changes common to both groups. Conversely, diagnosis-specific volume changes are associated with treatment effects and may represent pathophysiology-specific impacts of ECT. Elsevier 2023-05-03 /pmc/articles/PMC10193002/ /pubmed/37150022 http://dx.doi.org/10.1016/j.nicl.2023.103429 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
Kawashima, Hirotsugu
Yamasaki, Shimpei
Kubota, Manabu
Hazama, Masaaki
Fushimi, Yasutaka
Miyata, Jun
Murai, Toshiya
Suwa, Taro
Commonalities and differences in ECT-induced gray matter volume change between depression and schizophrenia
title Commonalities and differences in ECT-induced gray matter volume change between depression and schizophrenia
title_full Commonalities and differences in ECT-induced gray matter volume change between depression and schizophrenia
title_fullStr Commonalities and differences in ECT-induced gray matter volume change between depression and schizophrenia
title_full_unstemmed Commonalities and differences in ECT-induced gray matter volume change between depression and schizophrenia
title_short Commonalities and differences in ECT-induced gray matter volume change between depression and schizophrenia
title_sort commonalities and differences in ect-induced gray matter volume change between depression and schizophrenia
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193002/
https://www.ncbi.nlm.nih.gov/pubmed/37150022
http://dx.doi.org/10.1016/j.nicl.2023.103429
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