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Regulation of TREM2 expression by transcription factor YY1 and its protective effect against Alzheimer’s disease

TREM2 encoding the transmembrane receptor protein TREM2 is a risk gene of Alzheimer’s disease (AD), and the impairment of TREM2 functions in microglia due to mutations in TREM2 may significantly increase the risk of AD by promoting AD pathologies. However, how the expression of TREM2 is regulated an...

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Detalles Bibliográficos
Autores principales:	Lu, Yanhui, Huang, Xiaofeng, Liang, Wenping, Li, Yu, Xing, Mengen, Pan, Wenhao, Zhang, Yun, Wang, Zhe, Song, Weihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	JBC Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193014/ https://www.ncbi.nlm.nih.gov/pubmed/37044212 http://dx.doi.org/10.1016/j.jbc.2023.104688

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