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Delayed organising pneumonia in an immunocompromised host after a mild COVID-19 infection

Organising pneumonia after a mild COVID-19 infection has been increasingly reported and poses a diagnostic challenge to physicians especially in immunocompromised patients. We report a patient with a background of lymphoma in remission on rituximab who presented with prolonged and persistent fever a...

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Autores principales: Tiew, Han Wei, Tan, Joanne Wei Ping, Teo, Clarence Hai Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193096/
https://www.ncbi.nlm.nih.gov/pubmed/37192779
http://dx.doi.org/10.1136/bcr-2023-254737
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author Tiew, Han Wei
Tan, Joanne Wei Ping
Teo, Clarence Hai Yi
author_facet Tiew, Han Wei
Tan, Joanne Wei Ping
Teo, Clarence Hai Yi
author_sort Tiew, Han Wei
collection PubMed
description Organising pneumonia after a mild COVID-19 infection has been increasingly reported and poses a diagnostic challenge to physicians especially in immunocompromised patients. We report a patient with a background of lymphoma in remission on rituximab who presented with prolonged and persistent fever after recovering from a mild COVID-19 infection. The initial workup showed bilateral lower zone lung consolidation; however, the infective and autoimmune workup were unremarkable. Subsequently, a bronchoscopy with transbronchial lung biopsy confirmed the diagnosis of organising pneumonia. A tapering glucocorticoid regimen was commenced with prompt resolution of the patient’s clinical symptoms, and subsequent resolution of biochemical markers and radiological lung changes 3 months later. This case highlights the importance of early recognition of the diagnosis of organising pneumonia in immunocompromised populations after a mild COVID-19 infection as it shows promising response to glucocorticoid therapy.
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spelling pubmed-101930962023-05-19 Delayed organising pneumonia in an immunocompromised host after a mild COVID-19 infection Tiew, Han Wei Tan, Joanne Wei Ping Teo, Clarence Hai Yi BMJ Case Rep Case Reports: Unusual association of diseases/symptoms Organising pneumonia after a mild COVID-19 infection has been increasingly reported and poses a diagnostic challenge to physicians especially in immunocompromised patients. We report a patient with a background of lymphoma in remission on rituximab who presented with prolonged and persistent fever after recovering from a mild COVID-19 infection. The initial workup showed bilateral lower zone lung consolidation; however, the infective and autoimmune workup were unremarkable. Subsequently, a bronchoscopy with transbronchial lung biopsy confirmed the diagnosis of organising pneumonia. A tapering glucocorticoid regimen was commenced with prompt resolution of the patient’s clinical symptoms, and subsequent resolution of biochemical markers and radiological lung changes 3 months later. This case highlights the importance of early recognition of the diagnosis of organising pneumonia in immunocompromised populations after a mild COVID-19 infection as it shows promising response to glucocorticoid therapy. BMJ Publishing Group 2023-05-16 /pmc/articles/PMC10193096/ /pubmed/37192779 http://dx.doi.org/10.1136/bcr-2023-254737 Text en © BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.
spellingShingle Case Reports: Unusual association of diseases/symptoms
Tiew, Han Wei
Tan, Joanne Wei Ping
Teo, Clarence Hai Yi
Delayed organising pneumonia in an immunocompromised host after a mild COVID-19 infection
title Delayed organising pneumonia in an immunocompromised host after a mild COVID-19 infection
title_full Delayed organising pneumonia in an immunocompromised host after a mild COVID-19 infection
title_fullStr Delayed organising pneumonia in an immunocompromised host after a mild COVID-19 infection
title_full_unstemmed Delayed organising pneumonia in an immunocompromised host after a mild COVID-19 infection
title_short Delayed organising pneumonia in an immunocompromised host after a mild COVID-19 infection
title_sort delayed organising pneumonia in an immunocompromised host after a mild covid-19 infection
topic Case Reports: Unusual association of diseases/symptoms
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193096/
https://www.ncbi.nlm.nih.gov/pubmed/37192779
http://dx.doi.org/10.1136/bcr-2023-254737
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