Mbnl2 loss alters novel context processing and impairs object recognition memory

Patients with myotonic dystrophy type I (DM1) demonstrate visuospatial dysfunction and impaired performance in tasks requiring recognition or memory of figures and objects. In DM1, CUG expansion RNAs inactivate the muscleblind-like (MBNL) proteins. We show that constitutive Mbnl2 inactivation in Mbn...

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Detalles Bibliográficos
Autores principales: Khandelwal, Abinash, Cushman, Jesse, Choi, Jongkyu, Zhuravka, Irina, Rajbhandari, Abha, Valiulahi, Parvin, Li, Xiandu, Zhou, Chenyu, Comai, Lucio, Reddy, Sita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193234/
https://www.ncbi.nlm.nih.gov/pubmed/37216102
http://dx.doi.org/10.1016/j.isci.2023.106732

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