Cargando…

The Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate

Placental development relies on coordinated cell fate decisions governed by signalling inputs. However, little is known about how signalling cues are transformed into repressive mechanisms triggering lineage-specific transcriptional signatures. Here, we demonstrate that upon inhibition of the Fgf/Er...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lackner, Andreas, Müller, Michael, Gamperl, Magdalena, Stoeva, Delyana, Langmann, Olivia, Papuchova, Henrieta, Roitinger, Elisabeth, Dürnberger, Gerhard, Imre, Richard, Mechtler, Karl, Latos, Paulina A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193302/ https://www.ncbi.nlm.nih.gov/pubmed/37137875 http://dx.doi.org/10.1038/s41467-023-38101-8

Ejemplares similares

MSX2 safeguards syncytiotrophoblast fate of human trophoblast stem cells
por: Hornbachner, Ruth, et al.
Publicado: (2021)

Transcription factor networks in trophoblast development
por: Papuchova, Henrieta, et al.
Publicado: (2022)

Evolution of NCoR-1 and NCoR-2 corepressor alternative mRNA splicing in placental mammals
por: Privalsky, Martin L., et al.
Publicado: (2019)

Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases
por: Paluvai, Harikrishnareddy, et al.
Publicado: (2023)

NCoR controls glioblastoma tumor cell characteristics
por: Heldring, Nina, et al.
Publicado: (2014)

Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis
por: Korman, Benjamin, et al.
Publicado: (2018)

Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance
por: Gallardo, Fernando, et al.
Publicado: (2015)

CK2-NCoR signaling cascade promotes prostate tumorigenesis
por: Yoo, Jung-Yoon, et al.
Publicado: (2013)

NCoR1: Putting the Brakes on the Dendritic Cell Immune Tolerance
por: Ahad, Abdul, et al.
Publicado: (2019)

Loss of autophagy impairs physiological steatosis by accumulation of NCoR1
por: Takahashi, Shun-saku, et al.
Publicado: (2019)

Insights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex
por: Hudson, Gregg M., et al.
Publicado: (2015)

Autophagy regulates lipid metabolism through selective turnover of NCoR1
por: Saito, Tetsuya, et al.
Publicado: (2019)

Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer
por: Beilner, Daniel, et al.
Publicado: (2021)

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression
por: Yu, Lei, et al.
Publicado: (2018)

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection
por: Wang, Jianrong, et al.
Publicado: (2017)

The Role of Nuclear Receptor Corepressors NCoR1 and SMRT on Physiologic Function in the Adult Mouse
por: Ritter, Megan J, et al.
Publicado: (2021)

Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ
por: Mosure, Sarah A., et al.
Publicado: (2021)

Nuclear Receptor Corepressors NCoR1 and SMRT Plays Unique Roles in Central Nervous System
por: Amano, Izuki, et al.
Publicado: (2021)

Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis
por: Matsumura, Yoshihiro, et al.
Publicado: (2021)

MeCP2 co-ordinates liver lipid metabolism with the NCoR1/HDAC3 corepressor complex
por: Kyle, Stephanie M., et al.
Publicado: (2016)

COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR
por: Lu, Renquan, et al.
Publicado: (2016)

NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation
por: Sen, Kaushik, et al.
Publicado: (2022)

NCoR1 controls Mycobacterium tuberculosis growth in myeloid cells by regulating the AMPK-mTOR-TFEB axis
por: Biswas, Viplov Kumar, et al.
Publicado: (2023)

p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1
por: Shi, Min Yan, et al.
Publicado: (2023)

Chaperone-mediated autophagy dysregulation during aging impairs hepatic fatty acid oxidation via accumulation of NCoR1
por: Choi, You-Jin, et al.
Publicado: (2023)

Short linear motif acquisition, exon formation and alternative splicing determine a pathway to diversity for NCoR-family co-repressors
por: Short, Stephen, et al.
Publicado: (2015)

Specific ablation of the NCoR corepressor δ splice variant reveals alternative RNA splicing as a key regulator of hepatic metabolism
por: Goodson, Michael L., et al.
Publicado: (2020)

HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity
por: Szigety, Katherine M., et al.
Publicado: (2020)

SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling
por: Jha, Atimukta, et al.
Publicado: (2022)

Author Correction: p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1
por: Shi, Min Yan, et al.
Publicado: (2023)

GEI-8, a Homologue of Vertebrate Nuclear Receptor Corepressor NCoR/SMRT, Regulates Gonad Development and Neuronal Functions in Caenorhabditis elegans
por: Mikoláš, Pavol, et al.
Publicado: (2013)

A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes
por: Oswald, Franz, et al.
Publicado: (2016)

Autophagic Degradation of Misfolded Nuclear Receptor Co-repressor (NCoR) Is Linked to the Growth of Tumor Cells in HBX Positive Hepatocellular Carcinoma (HCC)
por: Tan, Su Yin, et al.
Publicado: (2019)

NCoR1 Protects Mice From Dextran Sodium Sulfate–Induced Colitis by Guarding Colonic Crypt Cells From Luminal Insult
por: Mennillo, Elvira, et al.
Publicado: (2020)

SUMOylation of PPARγ by Rosiglitazone Prevents LPS-Induced NCoR Degradation Mediating Down Regulation of Chemokines Expression in Renal Proximal Tubular Cells
por: Lu, Ying, et al.
Publicado: (2013)

The pregnane X receptor (PXR) and the nuclear receptor corepressor 2 (NCoR2) modulate cell growth in head and neck squamous cell carcinoma
por: Rigalli, Juan Pablo, et al.
Publicado: (2018)

Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis
por: Chen, Zhe, et al.
Publicado: (2021)

Interaction between poly(A)–binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response
por: Oliveira, A.G., et al.
Publicado: (2023)

miR-221 Alleviates the Ox-LDL-Induced Macrophage Inflammatory Response via the Inhibition of DNMT3b-Mediated NCoR Promoter Methylation
por: Ye, Jinshan, et al.
Publicado: (2019)

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells
por: Latos, Paulina A., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_kdab5nb1vgqfga9apto3kbebii