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Bioorthogonal Chemical Labeling Probes Targeting Sialic Acid Isomers for N-Glycan MALDI Imaging Mass Spectrometry of Tissues, Cells, and Biofluids

[Image: see text] Sialic acid isomers attached in either α2,3 or α2,6 linkage to glycan termini confer distinct chemical, biological, and pathological properties, but they cannot be distinguished by mass differences in traditional mass spectrometry experiments. Multiple derivatization strategies hav...

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Detalles Bibliográficos
Autores principales:	Lu, Xiaowei, McDowell, Colin T., Blaschke, Calvin R. K., Liu, Liping, Grimsley, Grace, Wisniewski, Luke, Gao, ChongFeng, Mehta, Anand S., Haab, Brian B., Angel, Peggi M., Drake, Richard R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193362/ https://www.ncbi.nlm.nih.gov/pubmed/37126482 http://dx.doi.org/10.1021/acs.analchem.2c04882

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