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Pregnancy Complications and Impact on Kidney Allograft After Kidney Transplantation in IgA Nephropathy
Pregnancy in kidney transplantation (KT) recipients has been challenging because of the high risk of maternal, fetal, and renal complications. Although patients with immunoglobulin A nephropathy (IgAN)-chronic kidney disease (CKD) are at a high risk for hypertension in pregnancy (HIP), the maternal...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193387/ https://www.ncbi.nlm.nih.gov/pubmed/37213487 http://dx.doi.org/10.3389/ti.2023.11220 |
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author | Oki, Rikako Unagami, Kohei Kakogawa, Jun Beppu, Hiroko Banno, Taro Yagisawa, Takafumi Kanzawa, Taichi Hirai, Toshihito Omoto, Kazuya Kitajima, Kumiko Shirakawa, Hiroki Hoshino, Junichi Takagi, Toshio Ishida, Hideki |
author_facet | Oki, Rikako Unagami, Kohei Kakogawa, Jun Beppu, Hiroko Banno, Taro Yagisawa, Takafumi Kanzawa, Taichi Hirai, Toshihito Omoto, Kazuya Kitajima, Kumiko Shirakawa, Hiroki Hoshino, Junichi Takagi, Toshio Ishida, Hideki |
author_sort | Oki, Rikako |
collection | PubMed |
description | Pregnancy in kidney transplantation (KT) recipients has been challenging because of the high risk of maternal, fetal, and renal complications. Although patients with immunoglobulin A nephropathy (IgAN)-chronic kidney disease (CKD) are at a high risk for hypertension in pregnancy (HIP), the maternal risk in KT recipients with IgAN as the etiology remains unclear. We retrospectively reviewed the medical records of pregnant KT recipients who delivered at our hospital. The incidence of maternal and fetal complications and the impact on kidney allografts between the group with IgAN as the primary kidney disease and the group with other primary diseases were compared. The analysis included 73 pregnancies in 64 KT recipients. The IgAN group had a higher incidence of HIP than the non-IgAN group (69% vs. 40%, p = 0.02). IgAN as primary kidney disease and interval from transplantation to conception were associated with HIP (OR 3.33 [1.11–9.92], p = 0.03, OR 0.83 [0.72–0.96], p < 0.01, respectively). The 20-year graft survival or prevention of CKD stage 5 in group with IgAN was lower than that in the group with other primary disease (p < 0.01). KT recipients should be informed of the risk of HIP and possibility of long-term worsening of postpartum renal function. |
format | Online Article Text |
id | pubmed-10193387 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101933872023-05-19 Pregnancy Complications and Impact on Kidney Allograft After Kidney Transplantation in IgA Nephropathy Oki, Rikako Unagami, Kohei Kakogawa, Jun Beppu, Hiroko Banno, Taro Yagisawa, Takafumi Kanzawa, Taichi Hirai, Toshihito Omoto, Kazuya Kitajima, Kumiko Shirakawa, Hiroki Hoshino, Junichi Takagi, Toshio Ishida, Hideki Transpl Int Health Archive Pregnancy in kidney transplantation (KT) recipients has been challenging because of the high risk of maternal, fetal, and renal complications. Although patients with immunoglobulin A nephropathy (IgAN)-chronic kidney disease (CKD) are at a high risk for hypertension in pregnancy (HIP), the maternal risk in KT recipients with IgAN as the etiology remains unclear. We retrospectively reviewed the medical records of pregnant KT recipients who delivered at our hospital. The incidence of maternal and fetal complications and the impact on kidney allografts between the group with IgAN as the primary kidney disease and the group with other primary diseases were compared. The analysis included 73 pregnancies in 64 KT recipients. The IgAN group had a higher incidence of HIP than the non-IgAN group (69% vs. 40%, p = 0.02). IgAN as primary kidney disease and interval from transplantation to conception were associated with HIP (OR 3.33 [1.11–9.92], p = 0.03, OR 0.83 [0.72–0.96], p < 0.01, respectively). The 20-year graft survival or prevention of CKD stage 5 in group with IgAN was lower than that in the group with other primary disease (p < 0.01). KT recipients should be informed of the risk of HIP and possibility of long-term worsening of postpartum renal function. Frontiers Media S.A. 2023-05-04 /pmc/articles/PMC10193387/ /pubmed/37213487 http://dx.doi.org/10.3389/ti.2023.11220 Text en Copyright © 2023 Oki, Unagami, Kakogawa, Beppu, Banno, Yagisawa, Kanzawa, Hirai, Omoto, Kitajima, Shirakawa, Hoshino, Takagi and Ishida. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Health Archive Oki, Rikako Unagami, Kohei Kakogawa, Jun Beppu, Hiroko Banno, Taro Yagisawa, Takafumi Kanzawa, Taichi Hirai, Toshihito Omoto, Kazuya Kitajima, Kumiko Shirakawa, Hiroki Hoshino, Junichi Takagi, Toshio Ishida, Hideki Pregnancy Complications and Impact on Kidney Allograft After Kidney Transplantation in IgA Nephropathy |
title | Pregnancy Complications and Impact on Kidney Allograft After Kidney Transplantation in IgA Nephropathy |
title_full | Pregnancy Complications and Impact on Kidney Allograft After Kidney Transplantation in IgA Nephropathy |
title_fullStr | Pregnancy Complications and Impact on Kidney Allograft After Kidney Transplantation in IgA Nephropathy |
title_full_unstemmed | Pregnancy Complications and Impact on Kidney Allograft After Kidney Transplantation in IgA Nephropathy |
title_short | Pregnancy Complications and Impact on Kidney Allograft After Kidney Transplantation in IgA Nephropathy |
title_sort | pregnancy complications and impact on kidney allograft after kidney transplantation in iga nephropathy |
topic | Health Archive |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193387/ https://www.ncbi.nlm.nih.gov/pubmed/37213487 http://dx.doi.org/10.3389/ti.2023.11220 |
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