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Poly(3,4-ethylenedioxythiophene):Polystyrene Sulfonate-Modified Electrode for the Detection of Furosemide in Pharmaceutical Products
[Image: see text] Furosemide (4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoyl benzoic acid) is a widely used, FDA-approved drug prescribed for several symptoms associated with heart, kidney, liver failure, or chronic high blood pressure. In this work, a glassy carbon working electrode modified with p...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193417/ https://www.ncbi.nlm.nih.gov/pubmed/37214665 http://dx.doi.org/10.1021/acsomega.3c00463 |
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author | Hossain, Md. Shamim Khaleque, Md. Abdul Ali, Md. Romzan Bacchu, Md. Sadek Hossain, Md. Ikram Aly Saad Aly, Mohamed Khan, Md. Zaved Hossain |
author_facet | Hossain, Md. Shamim Khaleque, Md. Abdul Ali, Md. Romzan Bacchu, Md. Sadek Hossain, Md. Ikram Aly Saad Aly, Mohamed Khan, Md. Zaved Hossain |
author_sort | Hossain, Md. Shamim |
collection | PubMed |
description | [Image: see text] Furosemide (4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoyl benzoic acid) is a widely used, FDA-approved drug prescribed for several symptoms associated with heart, kidney, liver failure, or chronic high blood pressure. In this work, a glassy carbon working electrode modified with poly(3,4-ethylenedioxythiophene):polystyrene sulfonate is developed to detect furosemide (FURO) with high sensitivity and precise selectivity. The modified electrode was also characterized using field emission scanning electron microscopy, attenuated total reflectance–Fourier transform infrared, and cyclic voltammetry. Here, an efficient and cost- and time-efficient technique to study the furosemide mechanism of reaction in an acidic liquid medium is presented. An electrochemical oxidation of loop diuretic furosemide was investigated in a supporting electrolyte, 0.01 M of phosphate buffer (at a pH level of 4.0) at 25 ± 0.1 °C using a differential pulse voltammetric (DPV) technique. Under optimized parameters, the developed sensor displays a wide detection range of furosemide concentrations of 6.0 × 10(–6) to 1.0 × 10(–4) M with a detection limit of 2.0 × 10(–6) M using DPV. The presented sensor offers a robust and high-precision technique with an excellent reproducibility to detect furosemide in as a real sample such as urine and pharmaceutical products. |
format | Online Article Text |
id | pubmed-10193417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-101934172023-05-19 Poly(3,4-ethylenedioxythiophene):Polystyrene Sulfonate-Modified Electrode for the Detection of Furosemide in Pharmaceutical Products Hossain, Md. Shamim Khaleque, Md. Abdul Ali, Md. Romzan Bacchu, Md. Sadek Hossain, Md. Ikram Aly Saad Aly, Mohamed Khan, Md. Zaved Hossain ACS Omega [Image: see text] Furosemide (4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoyl benzoic acid) is a widely used, FDA-approved drug prescribed for several symptoms associated with heart, kidney, liver failure, or chronic high blood pressure. In this work, a glassy carbon working electrode modified with poly(3,4-ethylenedioxythiophene):polystyrene sulfonate is developed to detect furosemide (FURO) with high sensitivity and precise selectivity. The modified electrode was also characterized using field emission scanning electron microscopy, attenuated total reflectance–Fourier transform infrared, and cyclic voltammetry. Here, an efficient and cost- and time-efficient technique to study the furosemide mechanism of reaction in an acidic liquid medium is presented. An electrochemical oxidation of loop diuretic furosemide was investigated in a supporting electrolyte, 0.01 M of phosphate buffer (at a pH level of 4.0) at 25 ± 0.1 °C using a differential pulse voltammetric (DPV) technique. Under optimized parameters, the developed sensor displays a wide detection range of furosemide concentrations of 6.0 × 10(–6) to 1.0 × 10(–4) M with a detection limit of 2.0 × 10(–6) M using DPV. The presented sensor offers a robust and high-precision technique with an excellent reproducibility to detect furosemide in as a real sample such as urine and pharmaceutical products. American Chemical Society 2023-05-04 /pmc/articles/PMC10193417/ /pubmed/37214665 http://dx.doi.org/10.1021/acsomega.3c00463 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Hossain, Md. Shamim Khaleque, Md. Abdul Ali, Md. Romzan Bacchu, Md. Sadek Hossain, Md. Ikram Aly Saad Aly, Mohamed Khan, Md. Zaved Hossain Poly(3,4-ethylenedioxythiophene):Polystyrene Sulfonate-Modified Electrode for the Detection of Furosemide in Pharmaceutical Products |
title | Poly(3,4-ethylenedioxythiophene):Polystyrene
Sulfonate-Modified
Electrode for the Detection of Furosemide in Pharmaceutical Products |
title_full | Poly(3,4-ethylenedioxythiophene):Polystyrene
Sulfonate-Modified
Electrode for the Detection of Furosemide in Pharmaceutical Products |
title_fullStr | Poly(3,4-ethylenedioxythiophene):Polystyrene
Sulfonate-Modified
Electrode for the Detection of Furosemide in Pharmaceutical Products |
title_full_unstemmed | Poly(3,4-ethylenedioxythiophene):Polystyrene
Sulfonate-Modified
Electrode for the Detection of Furosemide in Pharmaceutical Products |
title_short | Poly(3,4-ethylenedioxythiophene):Polystyrene
Sulfonate-Modified
Electrode for the Detection of Furosemide in Pharmaceutical Products |
title_sort | poly(3,4-ethylenedioxythiophene):polystyrene
sulfonate-modified
electrode for the detection of furosemide in pharmaceutical products |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193417/ https://www.ncbi.nlm.nih.gov/pubmed/37214665 http://dx.doi.org/10.1021/acsomega.3c00463 |
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