Molecular mechanisms involved in regulating protein activity and biological function of MST3

Mammalian sterile 20-like (Ste20-like) protein kinase 3 (MST3) or serine/threonine-protein kinase 24 (STK24) is a serine/threonine protein kinase that belongs to the mammalian STE20-like protein kinase family. MST3 is a pleiotropic protein that plays a critical role in regulating a variety of events...

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Autores principales: Qiu, Jing, Xiong, Junzhi, Jiang, Lu, Wang, Xinmin, Zhang, Kebin, Yu, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193606/
https://www.ncbi.nlm.nih.gov/pubmed/37202821
http://dx.doi.org/10.1186/s13008-023-00090-x
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author Qiu, Jing
Xiong, Junzhi
Jiang, Lu
Wang, Xinmin
Zhang, Kebin
Yu, Hua
author_facet Qiu, Jing
Xiong, Junzhi
Jiang, Lu
Wang, Xinmin
Zhang, Kebin
Yu, Hua
author_sort Qiu, Jing
collection PubMed
description Mammalian sterile 20-like (Ste20-like) protein kinase 3 (MST3) or serine/threonine-protein kinase 24 (STK24) is a serine/threonine protein kinase that belongs to the mammalian STE20-like protein kinase family. MST3 is a pleiotropic protein that plays a critical role in regulating a variety of events, including apoptosis, immune response, metabolism, hypertension, tumor progression, and development of the central nervous system. The MST3-mediated regulation is intricately related to protein activity, post-translational modification, and subcellular location. Here, we review the recent progress on the regulatory mechanisms against MST3 and its-mediated control of disease progression.
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spelling pubmed-101936062023-05-19 Molecular mechanisms involved in regulating protein activity and biological function of MST3 Qiu, Jing Xiong, Junzhi Jiang, Lu Wang, Xinmin Zhang, Kebin Yu, Hua Cell Div Review Mammalian sterile 20-like (Ste20-like) protein kinase 3 (MST3) or serine/threonine-protein kinase 24 (STK24) is a serine/threonine protein kinase that belongs to the mammalian STE20-like protein kinase family. MST3 is a pleiotropic protein that plays a critical role in regulating a variety of events, including apoptosis, immune response, metabolism, hypertension, tumor progression, and development of the central nervous system. The MST3-mediated regulation is intricately related to protein activity, post-translational modification, and subcellular location. Here, we review the recent progress on the regulatory mechanisms against MST3 and its-mediated control of disease progression. BioMed Central 2023-05-18 /pmc/articles/PMC10193606/ /pubmed/37202821 http://dx.doi.org/10.1186/s13008-023-00090-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Qiu, Jing
Xiong, Junzhi
Jiang, Lu
Wang, Xinmin
Zhang, Kebin
Yu, Hua
Molecular mechanisms involved in regulating protein activity and biological function of MST3
title Molecular mechanisms involved in regulating protein activity and biological function of MST3
title_full Molecular mechanisms involved in regulating protein activity and biological function of MST3
title_fullStr Molecular mechanisms involved in regulating protein activity and biological function of MST3
title_full_unstemmed Molecular mechanisms involved in regulating protein activity and biological function of MST3
title_short Molecular mechanisms involved in regulating protein activity and biological function of MST3
title_sort molecular mechanisms involved in regulating protein activity and biological function of mst3
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193606/
https://www.ncbi.nlm.nih.gov/pubmed/37202821
http://dx.doi.org/10.1186/s13008-023-00090-x
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