Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model

BACKGROUND: This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury. RESULTS: The skin-derived precursor Schwann cells-treatment significantly restored e...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Xiaolei, Yang, Wende, Nie, Pan, Zhang, Zhenbin, Chen, Zehong, Wei, Hongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193723/
https://www.ncbi.nlm.nih.gov/pubmed/37198550
http://dx.doi.org/10.1186/s12610-023-00187-x
Descripción
Sumario:BACKGROUND: This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury. RESULTS: The skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum. CONCLUSIONS: Implantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury.

Ejemplares similares