Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model

BACKGROUND: This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury. RESULTS: The skin-derived precursor Schwann cells-treatment significantly restored e...

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Autores principales: Ma, Xiaolei, Yang, Wende, Nie, Pan, Zhang, Zhenbin, Chen, Zehong, Wei, Hongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193723/
https://www.ncbi.nlm.nih.gov/pubmed/37198550
http://dx.doi.org/10.1186/s12610-023-00187-x
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author Ma, Xiaolei
Yang, Wende
Nie, Pan
Zhang, Zhenbin
Chen, Zehong
Wei, Hongbo
author_facet Ma, Xiaolei
Yang, Wende
Nie, Pan
Zhang, Zhenbin
Chen, Zehong
Wei, Hongbo
author_sort Ma, Xiaolei
collection PubMed
description BACKGROUND: This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury. RESULTS: The skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum. CONCLUSIONS: Implantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury.
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spelling pubmed-101937232023-05-19 Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model Ma, Xiaolei Yang, Wende Nie, Pan Zhang, Zhenbin Chen, Zehong Wei, Hongbo Basic Clin Androl Research Article BACKGROUND: This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury. RESULTS: The skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum. CONCLUSIONS: Implantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury. BioMed Central 2023-05-18 /pmc/articles/PMC10193723/ /pubmed/37198550 http://dx.doi.org/10.1186/s12610-023-00187-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Ma, Xiaolei
Yang, Wende
Nie, Pan
Zhang, Zhenbin
Chen, Zehong
Wei, Hongbo
Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model
title Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model
title_full Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model
title_fullStr Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model
title_full_unstemmed Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model
title_short Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model
title_sort implantation of skin-derived precursor schwann cells improves erectile function in a bilateral cavernous nerve injury rat model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193723/
https://www.ncbi.nlm.nih.gov/pubmed/37198550
http://dx.doi.org/10.1186/s12610-023-00187-x
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