Cargando…

Biological Mechanism-based Neurology and Psychiatry: A BACE1/2 and Downstream Pathway Model

In oncology, comprehensive omics and functional enrichment studies have led to an extensive profiling of (epi)genetic and neurobiological alterations that can be mapped onto a single tumor’s clinical phenotype and divergent clinical phenotypes expressing common pathophysiological pathways. Consequen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hampel, Harald, Caruso, Giuseppe, Nisticò, Robert, Piccioni, Gaia, Mercuri, Nicola B., Giorgi, Filippo Sean, Ferrarelli, Fabio, Lemercier, Pablo, Caraci, Filippo, Lista, Simone, Vergallo, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers 2023
Materias:	Medicine, Neurology, Pharmacology, Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193755/ https://www.ncbi.nlm.nih.gov/pubmed/34852743 http://dx.doi.org/10.2174/1570159X19666211201095701

Ejemplares similares

β-Secretase1 biological markers for Alzheimer’s disease: state-of-art of validation and qualification
por: Hampel, Harald, et al.
Publicado: (2020)

Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer’s Precision Medicine and Pharmacology
por: Hampel, Harald, et al.
Publicado: (2019)

Meet the Co-Editor
por: Caraci, Filippo
Publicado: (2022)

Meet the Co-Editor
por: Caraci, Filippo
Publicado: (2023)

Rescue of Noradrenergic System as a Novel Pharmacological Strategy in the Treatment of Chronic Pain: Focus on Microglia Activation
por: Caraci, Filippo, et al.
Publicado: (2019)

The Many Faces of Mitochondrial Dysfunction in Depression: From Pathology to Treatment
por: Caruso, Giuseppe, et al.
Publicado: (2019)

Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology
por: Finberg, John P. M., et al.
Publicado: (2016)

New drugs in psychiatry: focus on new pharmacological targets
por: Caraci, Filippo, et al.
Publicado: (2017)

Post-Translational Modifications of BACE1 in Alzheimer's Disease
por: Wen, Wen, et al.
Publicado: (2022)

A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease
por: Hampel, Harald, et al.
Publicado: (2020)

Age and sex impact plasma NFL and t-Tau trajectories in individuals with subjective memory complaints: a 3-year follow-up study
por: Baldacci, Filippo, et al.
Publicado: (2020)

Ginkgolic Acid Protects against Aβ-Induced Synaptic Dysfunction in the Hippocampus
por: Mango, Dalila, et al.
Publicado: (2016)

Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D(3) Receptor Blockade
por: Torrisi, Sebastiano Alfio, et al.
Publicado: (2017)

Editorial: Epilepsy in older adults: From physiopathology to improvements in diagnosis and management
por: Romigi, Andrea, et al.
Publicado: (2022)

Design, in silico and pharmacological evaluation of a peptide inhibitor of BACE-1
por: Boldin, Renata, et al.
Publicado: (2023)

MiRNA-15b and miRNA-125b are associated with regional Aβ-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints
por: Vergallo, Andrea, et al.
Publicado: (2021)

Antioxidant Activity of Fluoxetine and Vortioxetine in a Non-Transgenic Animal Model of Alzheimer’s Disease
por: Caruso, Giuseppe, et al.
Publicado: (2021)

Prenatal stress induces a depressive-like phenotype in adolescent rats: The key role of TGF-β1 pathway
por: Fidilio, Annamaria, et al.
Publicado: (2022)

BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer’s Disease Markers in Elderly Healthy Participants
por: Timmers, Maarten, et al.
Publicado: (2017)

BACE1: A Key Regulator in Alzheimer’s Disease Progression and Current Development of its Inhibitors
por: Patel, Smith, et al.
Publicado: (2022)

Fluoxetine and Vortioxetine Reverse Depressive-Like Phenotype and Memory Deficits Induced by Aβ(1-42) Oligomers in Mice: A Key Role of Transforming Growth Factor-β1
por: Torrisi, Sebastiano Alfio, et al.
Publicado: (2019)

Perspective on mTOR-dependent Protection in Status Epilepticus
por: Biagioni, Francesca, et al.
Publicado: (2022)

Biomarkers for Alzheimer’s Disease (AD) and the Application of Precision Medicine
por: Lukiw, Walter J., et al.
Publicado: (2020)

The Sars-Cov-2 Pandemic and the Brave New Digital World of Environmental Enrichment to Prevent Brain Aging and Cognitive Decline
por: Hampel, Harald, et al.
Publicado: (2020)

The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling
por: Fidilio, Annamaria, et al.
Publicado: (2021)

Microfluidic/HPLC combination to study carnosine protective activity on challenged human microglia: Focus on oxidative stress and energy metabolism
por: Privitera, Anna, et al.
Publicado: (2023)

Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
por: Meier, Silvio R., et al.
Publicado: (2018)

Fluoxetine Prevents Aβ(1-42)-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-β1
por: Caraci, Filippo, et al.
Publicado: (2016)

Concatenation of molecular docking and molecular simulation of BACE-1, γ-secretase targeted ligands: in pursuit of Alzheimer’s treatment
por: Jabir, Nasimudeen R., et al.
Publicado: (2021)

Pharmacokinetic Interactions of Clinical Interest Between Direct Oral Anticoagulants and Antiepileptic Drugs
por: Galgani, Alessandro, et al.
Publicado: (2018)

Corrigendum: Pharmacokinetic Interactions of Clinical Interest Between Direct Oral Anticoagulants and Antiepileptic Drugs
por: Galgani, Alessandro, et al.
Publicado: (2020)

Neurology and Psychiatry
por: Ell, P J, et al.
Publicado: (1998)

Distinct limbic connectivity in left and right benign mesial temporal lobe epilepsy: Evidence from a resting state functional MRI study
por: Pizzanelli, Chiara, et al.
Publicado: (2022)

Gap Junctions and Connexins in Microglia-Related Oxidative Stress and Neuroinflammation: Perspectives for Drug Discovery
por: Caruso, Giuseppe, et al.
Publicado: (2023)

Basal Forebrain Volume, but Not Hippocampal Volume, Is a Predictor of Global Cognitive Decline in Patients With Alzheimer's Disease Treated With Cholinesterase Inhibitors
por: Teipel, Stefan J., et al.
Publicado: (2018)

Aptamers as biomarkers for neurological disorders. Proof of concept in transgenic mice
por: Lecocq, Soizic, et al.
Publicado: (2018)

Blood-based systems biology biomarkers for next-generation clinical trials in Alzheimer’s disease 
por: Hampel, Harald, et al.
Publicado: (2019)

Access to Innovative Neurological Drugs in Europe: Alignment of Health Technology Assessments Among Three European Countries
por: Gozzo, Lucia, et al.
Publicado: (2022)

Cytotoxic and Pro-Apoptotic Effects of a Sub-Toxic Concentration of Fluvastatin on OVCAR3 Ovarian Cancer Cells After its Optimized Formulation to Melittin Nano-Conjugates
por: Badr-Eldin, Shaimaa M., et al.
Publicado: (2021)

Pharmacogenetics in Psychiatry: An Update on Clinical Usability
por: van Schaik, Ron H. N., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_t801kcnqgb6bcs5lhf6b30p9gh