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Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages

Fats are essential in healthy diets, but how dietary fats affect immune cell function and overall health is not well understood. Mimicking human high-fat diets (HFDs), which are rich in different fatty acid (FA) components, we fed mice various HFDs from different fat sources, including fish oil and...

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Autores principales: Hao, Jiaqing, Jin, Rong, Zeng, Jun, Hua, Yuan, Yorek, Matthew S., Liu, Lianliang, Mandal, Anita, Li, Junling, Zheng, Huaiyu, Sun, Yanwen, Yi, Yanmei, Yin, Di, Zheng, Qi, Li, Xiaohong, Ng, Chin K., Rouchka, Eric C., Egilmez, Nejat K., Jabbari, Ali, Li, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193786/
https://www.ncbi.nlm.nih.gov/pubmed/36516778
http://dx.doi.org/10.1016/j.celrep.2022.111804
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author Hao, Jiaqing
Jin, Rong
Zeng, Jun
Hua, Yuan
Yorek, Matthew S.
Liu, Lianliang
Mandal, Anita
Li, Junling
Zheng, Huaiyu
Sun, Yanwen
Yi, Yanmei
Yin, Di
Zheng, Qi
Li, Xiaohong
Ng, Chin K.
Rouchka, Eric C.
Egilmez, Nejat K.
Jabbari, Ali
Li, Bing
author_facet Hao, Jiaqing
Jin, Rong
Zeng, Jun
Hua, Yuan
Yorek, Matthew S.
Liu, Lianliang
Mandal, Anita
Li, Junling
Zheng, Huaiyu
Sun, Yanwen
Yi, Yanmei
Yin, Di
Zheng, Qi
Li, Xiaohong
Ng, Chin K.
Rouchka, Eric C.
Egilmez, Nejat K.
Jabbari, Ali
Li, Bing
author_sort Hao, Jiaqing
collection PubMed
description Fats are essential in healthy diets, but how dietary fats affect immune cell function and overall health is not well understood. Mimicking human high-fat diets (HFDs), which are rich in different fatty acid (FA) components, we fed mice various HFDs from different fat sources, including fish oil and cocoa butter. Mice consuming the fish oil HFD exhibit a hair-loss phenotype. Further studies show that omega-3 (n-3) FAs in fish oil promote atypical infiltration of CD207(−) (langerin(−)) myeloid macrophages in skin dermis, which induce hair loss through elevated TNF-α signaling. Mechanistically, epidermal fatty acid binding protein (E-FABP) is demonstrated to play an essential role in inducing TNF-α-mediated hair loss by activating the n-3 FA/ROS/IL-36 signaling pathway in dermal resident macrophages. Absence of E-FABP abrogates fish oil HFD-induced murine hair loss. Altogether, these findings support a role for E-FABP as a lipid sensor mediating n-3 FA-regulated macrophage function and skin health.
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spelling pubmed-101937862023-05-18 Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages Hao, Jiaqing Jin, Rong Zeng, Jun Hua, Yuan Yorek, Matthew S. Liu, Lianliang Mandal, Anita Li, Junling Zheng, Huaiyu Sun, Yanwen Yi, Yanmei Yin, Di Zheng, Qi Li, Xiaohong Ng, Chin K. Rouchka, Eric C. Egilmez, Nejat K. Jabbari, Ali Li, Bing Cell Rep Article Fats are essential in healthy diets, but how dietary fats affect immune cell function and overall health is not well understood. Mimicking human high-fat diets (HFDs), which are rich in different fatty acid (FA) components, we fed mice various HFDs from different fat sources, including fish oil and cocoa butter. Mice consuming the fish oil HFD exhibit a hair-loss phenotype. Further studies show that omega-3 (n-3) FAs in fish oil promote atypical infiltration of CD207(−) (langerin(−)) myeloid macrophages in skin dermis, which induce hair loss through elevated TNF-α signaling. Mechanistically, epidermal fatty acid binding protein (E-FABP) is demonstrated to play an essential role in inducing TNF-α-mediated hair loss by activating the n-3 FA/ROS/IL-36 signaling pathway in dermal resident macrophages. Absence of E-FABP abrogates fish oil HFD-induced murine hair loss. Altogether, these findings support a role for E-FABP as a lipid sensor mediating n-3 FA-regulated macrophage function and skin health. 2022-12-13 /pmc/articles/PMC10193786/ /pubmed/36516778 http://dx.doi.org/10.1016/j.celrep.2022.111804 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Hao, Jiaqing
Jin, Rong
Zeng, Jun
Hua, Yuan
Yorek, Matthew S.
Liu, Lianliang
Mandal, Anita
Li, Junling
Zheng, Huaiyu
Sun, Yanwen
Yi, Yanmei
Yin, Di
Zheng, Qi
Li, Xiaohong
Ng, Chin K.
Rouchka, Eric C.
Egilmez, Nejat K.
Jabbari, Ali
Li, Bing
Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages
title Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages
title_full Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages
title_fullStr Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages
title_full_unstemmed Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages
title_short Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages
title_sort consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193786/
https://www.ncbi.nlm.nih.gov/pubmed/36516778
http://dx.doi.org/10.1016/j.celrep.2022.111804
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