Cargando…

Cantharidin suppresses hepatocellular carcinoma development by regulating EZH2/H3K27me3-dependent cell cycle progression and antitumour immune response

BACKGROUND: Cantharidin (CTD) is a major ingredient of cantharis (Mylabris phalerata Pallas) and has been used extensively in traditional Chinese medicines. It has been shown to exhibit anticancer activity in multiple types of cancer, especially hepatocellular carcinoma (HCC). However, there is no s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Jia, Deng, Xiu ling, Ma, Shi qi, hui Li, Yu, Gao, Yu min, Shi, Gui tao, Wang, Hai sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193799/ https://www.ncbi.nlm.nih.gov/pubmed/37202806 http://dx.doi.org/10.1186/s12906-023-03975-0

Ejemplares similares

Integrative analysis of the molecular signature of target genes involved in the antitumor effects of cantharidin on hepatocellular carcinoma
por: Yan, Jia, et al.
Publicado: (2023)

EZH2/H3K27Me3 and phosphorylated EZH2 predict chemotherapy response and prognosis in ovarian cancer
por: Sun, Si, et al.
Publicado: (2020)

EZH2-mediated H3K27me3 inhibits ACE2 expression
por: Li, Yuanyuan, et al.
Publicado: (2020)

The EZH2–PRC2–H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion
por: Fukui, Yamato, et al.
Publicado: (2023)

EZH2-Mediated H3K27me3 Targets Transcriptional Circuits of Neuronal Differentiation
por: Buontempo, Serena, et al.
Publicado: (2022)

Inhibition of EZH2 Promotes Human Embryonic Stem Cell Differentiation into Mesoderm by Reducing H3K27me3
por: Yu, Yongxin, et al.
Publicado: (2018)

Inhibition of EZH2 Promotes Human Embryonic Stem Cell Differentiation into Mesoderm by Reducing H3K27me3
por: Yu, Yongxin, et al.
Publicado: (2017)

Role of S100A3 in human hepatocellular carcinoma and the anticancer effect of sodium cantharidinate
por: Tao, Ran, et al.
Publicado: (2017)

EZH2 dependent H3K27me3 is involved in epigenetic silencing of ID4 in prostate cancer
por: Chinaranagari, Swathi, et al.
Publicado: (2014)

Remarkable Synergy When Combining EZH2 Inhibitors with YM155 Is H3K27me3-Independent
por: Yang, Jun, et al.
Publicado: (2022)

EZH2-mediated H3K27me3 is a predictive biomarker and therapeutic target in uveal melanoma
por: Hou, Chen, et al.
Publicado: (2022)

EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis
por: Verma, Ayushi, et al.
Publicado: (2022)

Histone H3K4me3 and H3K27me3 regulatory genes control stable transmission of an epimutation in rice
por: Chen, Xiangsong, et al.
Publicado: (2015)

EZH2-H3K27me3-mediated silencing of mir-139-5p inhibits cellular senescence in hepatocellular carcinoma by activating TOP2A
por: Wang, Ke, et al.
Publicado: (2023)

Androgens regulate ovarian gene expression by balancing Ezh2-Jmjd3 mediated H3K27me3 dynamics
por: Roy, Sambit, et al.
Publicado: (2021)

Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming
por: Rao, Radhika Arasala, et al.
Publicado: (2015)

H3K27me3 and EZH2 expression in melanoma: relevance for melanoma progression and response to immune checkpoint blockade
por: Hoffmann, Friederike, et al.
Publicado: (2020)

Role of EZH2-mediated H3K27me3 in placental ADAM12-S expression: implications for fetoplacental growth
por: Zhu, Ya-nan, et al.
Publicado: (2022)

EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers
por: Au, Sandy Leung-Kuen, et al.
Publicado: (2013)

Profiling of H3K4me3 and H3K27me3 and Their Roles in Gene Subfunctionalization in Allotetraploid Cotton
por: Zhang, Aicen, et al.
Publicado: (2021)

Correction: EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers
por: Au, Sandy Leung-Kuen, et al.
Publicado: (2014)

Prognostic implications of polycomb proteins ezh2, suz12, and eed1 and histone modification by H3K27me3 in sarcoma
por: Cho, Yong Jin, et al.
Publicado: (2018)

FBP1 knockdown decreases ovarian cancer formation and cisplatin resistance through EZH2-mediated H3K27me3
por: Xiong, Xifeng, et al.
Publicado: (2022)

Azithromycin attenuates wheezing after pulmonary inflammation through inhibiting histone H3K27me3 hypermethylation mediated by EZH2
por: Wu, Shuqi, et al.
Publicado: (2023)

The EZH2-H3K27me3 axis modulates aberrant transcription and apoptosis in cyclophosphamide-induced ovarian granulosa cell injury
por: Chen, Yingyan, et al.
Publicado: (2023)

Distinct H3K27me3 and H3K27ac Modifications in Neural Tube Defects Induced by Benzo[a]pyrene
por: Lin, Shanshan, et al.
Publicado: (2023)

EZH2 Methyltransferase and H3K27 Methylation in Breast Cancer
por: Yoo, Kyung Hyun, et al.
Publicado: (2011)

EZH2 Regulates ANXA6 Expression via H3K27me3 and Is Involved in Angiotensin II-Induced Vascular Smooth Muscle Cell Senescence
por: Li, Yuejin, et al.
Publicado: (2022)

Long non-coding RNA FOXP4-AS1 facilitates the biological functions of hepatocellular carcinoma cells via downregulating ZC3H12D by mediating H3K27me3 through recruitment of EZH2
por: Ye, Junfeng, et al.
Publicado: (2021)

PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome
por: Meng, Tie-Gang, et al.
Publicado: (2020)

Prognostic Value of Polycomb Proteins EZH2, BMI1 and SUZ12 and Histone Modification H3K27me3 in Colorectal Cancer
por: Benard, Anne, et al.
Publicado: (2014)

LINC00114 stimulates growth and glycolysis of esophageal cancer cells by recruiting EZH2 to enhance H3K27me3 of DLC1
por: Qin, Jianzhang, et al.
Publicado: (2022)

Astronauts Plasma-Derived Exosomes Induced Aberrant EZH2-Mediated H3K27me3 Epigenetic Regulation of the Vitamin D Receptor
por: Bisserier, Malik, et al.
Publicado: (2022)

Quantification of Histone H3 Lys27 Trimethylation (H3K27me3) by High-Throughput Microscopy Enables Cellular Large-Scale Screening for Small-Molecule EZH2 Inhibitors
por: Luense, Svenja, et al.
Publicado: (2015)

H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development
por: Yu, Yue, et al.
Publicado: (2023)

The Pseudogene DUXAP8 Promotes Colorectal Cancer Cell Proliferation, Invasion, and Migration by Inducing Epithelial-Mesenchymal Transition Through Interacting with EZH2 and H3K27me3
por: He, Wenjing, et al.
Publicado: (2020)

Interplay of miR-137 and EZH2 contributes to the genome-wide redistribution of H3K27me3 underlying the Pb-induced memory impairment
por: Gu, Xiaozhen, et al.
Publicado: (2019)

The BAH domain of BAHD1 is a histone H3K27me3 reader
por: Zhao, Dan, et al.
Publicado: (2016)

Development of 11-DGA-3-O-Gal-Modified Cantharidin Liposomes for Treatment of Hepatocellular Carcinoma
por: Zhou, Lili, et al.
Publicado: (2019)

Intermittent High Glucose Elevates Nuclear Localization of EZH2 to Cause H3K27me3-Dependent Repression of KLF2 Leading to Endothelial Inflammation
por: Thakar, Sumukh, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_j7e33m1qgt0nk0m746k9t1lbtm