Preoperative chemoradiotherapy using tegafur/uracil, oral leucovorin, and irinotecan (TEGAFIRI) followed by oxaliplatin-based chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: the study protocol for a phase II trial

BACKGROUND: Total neoadjuvant therapy (TNT) is a novel treatment strategy that is an alternative to preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). However, an optimal protocol for TNT has not yet been established. The present study will be an open-label, single-arm,...

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Detalles Bibliográficos
Autores principales: Abe, Shinya, Kawai, Kazushige, Nozawa, Hiroaki, Sasaki, Kazuhito, Murono, Koji, Emoto, Shigenobu, Yokoyama, Yuichiro, Matsuzaki, Hiroyuki, Nagai, Yuzo, Yoshioka, Yuichiro, Shinagawa, Takahide, Sonoda, Hirofumi, Yamamoto, Yoko, Oba, Koji, Ishihara, Soichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193805/
https://www.ncbi.nlm.nih.gov/pubmed/37198556
http://dx.doi.org/10.1186/s12885-023-10941-z

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