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Unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mapping

BACKGROUND: It is unknown which features of unipolar atrial electrogram (U-AEGM) morphology are affected by ageing and whether age-related changes in U-AEGM morphology are equally distributed throughout the right and left atria. PATIENTS AND METHODS: Epicardial high-resolution mapping was performed...

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Autores principales: Ye, Ziliang, van Schie, Mathijs S., Heida, Annejet, van Staveren, Lianne N., van Schaagen, Frank R. N., Taverne, Yannick J. H. J., de Groot, Natasja M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193902/
https://www.ncbi.nlm.nih.gov/pubmed/37194486
http://dx.doi.org/10.1080/07853890.2023.2193426
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author Ye, Ziliang
van Schie, Mathijs S.
Heida, Annejet
van Staveren, Lianne N.
van Schaagen, Frank R. N.
Taverne, Yannick J. H. J.
de Groot, Natasja M. S.
author_facet Ye, Ziliang
van Schie, Mathijs S.
Heida, Annejet
van Staveren, Lianne N.
van Schaagen, Frank R. N.
Taverne, Yannick J. H. J.
de Groot, Natasja M. S.
author_sort Ye, Ziliang
collection PubMed
description BACKGROUND: It is unknown which features of unipolar atrial electrogram (U-AEGM) morphology are affected by ageing and whether age-related changes in U-AEGM morphology are equally distributed throughout the right and left atria. PATIENTS AND METHODS: Epicardial high-resolution mapping was performed in patients undergoing coronary artery bypass grafting surgery during sinus rhythm (SR). Mapping areas include the right atrium (RA), left atrium (LA), pulmonary vein area (PVA) and Bachmann’s bundle (BB). Patients were categorized into a young (age < 60) and aged (age ≥ 60) group. U-AEGM were classified as single potentials (SPs, one deflection), short double potentials (SDPs, deflection interval ≤ 15ms), long double potentials (LDPs, deflection interval > 15ms) and fractionated potentials (FPs, ≥3 deflections). RESULTS: A total of 213 patients (age: 67 (59–73) years; young group N = 58, aged group N = 155) were included. Only at BB, the proportion of SPs (p = 0.007) was significantly higher in the young group, while the proportion of SDPs (p = 0.051), LDPs (p = 0.004) and FPs (p = 0.006) was higher in the aged group. After adjusting for potential confounders, older age was associated with a reduction in SPs [regression coefficient (β): −6.33, 95% confident interval (CI): −10.37 to −2.30] at the expense of an increased proportion of SDPs (β: 2.49, 95% CI: 0.09 to 4.89), LDPs (β: 1.94, 95% CI: 0.21 to 3.68) and FPs (β: 1.90, 95% CI: 0.62 to 3.18). CONCLUSIONS: Age-related remodeling particularly affects BB as indicated by the decreased amount of non-SP at this location in the elderly. KEY MESSAGES: Ageing preferentially affects the morphology of unipolar atrial electrograms recorded at Bachmann’s bundle. At Bachmann’s bundle, the proportion of short double-, long double- and fractionated potentials increase during ageing at the expense of a decrease in the proportion of single potentials, reflecting aggravation of abnormalities in conduction. The increase in abnormal unipolar atrial electrograms at Bachmann’s bundle during ageing supports the concept that Bachmann’s bundle may play an important role in development of age-related arrhythmias such as atrial fibrillation.
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spelling pubmed-101939022023-05-19 Unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mapping Ye, Ziliang van Schie, Mathijs S. Heida, Annejet van Staveren, Lianne N. van Schaagen, Frank R. N. Taverne, Yannick J. H. J. de Groot, Natasja M. S. Ann Med Cardiology & Cardiovascular Disorders BACKGROUND: It is unknown which features of unipolar atrial electrogram (U-AEGM) morphology are affected by ageing and whether age-related changes in U-AEGM morphology are equally distributed throughout the right and left atria. PATIENTS AND METHODS: Epicardial high-resolution mapping was performed in patients undergoing coronary artery bypass grafting surgery during sinus rhythm (SR). Mapping areas include the right atrium (RA), left atrium (LA), pulmonary vein area (PVA) and Bachmann’s bundle (BB). Patients were categorized into a young (age < 60) and aged (age ≥ 60) group. U-AEGM were classified as single potentials (SPs, one deflection), short double potentials (SDPs, deflection interval ≤ 15ms), long double potentials (LDPs, deflection interval > 15ms) and fractionated potentials (FPs, ≥3 deflections). RESULTS: A total of 213 patients (age: 67 (59–73) years; young group N = 58, aged group N = 155) were included. Only at BB, the proportion of SPs (p = 0.007) was significantly higher in the young group, while the proportion of SDPs (p = 0.051), LDPs (p = 0.004) and FPs (p = 0.006) was higher in the aged group. After adjusting for potential confounders, older age was associated with a reduction in SPs [regression coefficient (β): −6.33, 95% confident interval (CI): −10.37 to −2.30] at the expense of an increased proportion of SDPs (β: 2.49, 95% CI: 0.09 to 4.89), LDPs (β: 1.94, 95% CI: 0.21 to 3.68) and FPs (β: 1.90, 95% CI: 0.62 to 3.18). CONCLUSIONS: Age-related remodeling particularly affects BB as indicated by the decreased amount of non-SP at this location in the elderly. KEY MESSAGES: Ageing preferentially affects the morphology of unipolar atrial electrograms recorded at Bachmann’s bundle. At Bachmann’s bundle, the proportion of short double-, long double- and fractionated potentials increase during ageing at the expense of a decrease in the proportion of single potentials, reflecting aggravation of abnormalities in conduction. The increase in abnormal unipolar atrial electrograms at Bachmann’s bundle during ageing supports the concept that Bachmann’s bundle may play an important role in development of age-related arrhythmias such as atrial fibrillation. Taylor & Francis 2023-05-17 /pmc/articles/PMC10193902/ /pubmed/37194486 http://dx.doi.org/10.1080/07853890.2023.2193426 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Cardiology & Cardiovascular Disorders
Ye, Ziliang
van Schie, Mathijs S.
Heida, Annejet
van Staveren, Lianne N.
van Schaagen, Frank R. N.
Taverne, Yannick J. H. J.
de Groot, Natasja M. S.
Unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mapping
title Unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mapping
title_full Unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mapping
title_fullStr Unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mapping
title_full_unstemmed Unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mapping
title_short Unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mapping
title_sort unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mapping
topic Cardiology & Cardiovascular Disorders
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193902/
https://www.ncbi.nlm.nih.gov/pubmed/37194486
http://dx.doi.org/10.1080/07853890.2023.2193426
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