The potential regulatory role of RNA methylation in ovarian cancer

Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification. RNA methylation is essential for regulating biological processes such as RNA transcription, splicing, structure, stability, a...

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Autores principales: Zhao, Shijie, Zhang, Mengxue, Zhu, Xiaolan, Xing, Jie, Zhou, Jiaming, Yin, Xinming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193916/
https://www.ncbi.nlm.nih.gov/pubmed/37194218
http://dx.doi.org/10.1080/15476286.2023.2213915
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author Zhao, Shijie
Zhang, Mengxue
Zhu, Xiaolan
Xing, Jie
Zhou, Jiaming
Yin, Xinming
author_facet Zhao, Shijie
Zhang, Mengxue
Zhu, Xiaolan
Xing, Jie
Zhou, Jiaming
Yin, Xinming
author_sort Zhao, Shijie
collection PubMed
description Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification. RNA methylation is essential for regulating biological processes such as RNA transcription, splicing, structure, stability, and translation. Its dysfunction is strongly associated with the development of human malignancies. Research advances with respect to the regulatory role of RNA modifications in ovarian cancer include N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), and N7-methylguanosine (m7G). Numerous studies have demonstrated that epigenetic modifications of RNA can influence the progression and metastasis of ovarian cancer and may provide excellent targets for cancer therapy. This review highlights advances in research on RNA methylation modifications and ovarian cancer prognosis, carcinogenesis, and resistance, which could provide a theoretical foundation for designing therapeutic strategies for ovarian cancer based on RNA methylation modifications.
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spelling pubmed-101939162023-05-19 The potential regulatory role of RNA methylation in ovarian cancer Zhao, Shijie Zhang, Mengxue Zhu, Xiaolan Xing, Jie Zhou, Jiaming Yin, Xinming RNA Biol Review Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification. RNA methylation is essential for regulating biological processes such as RNA transcription, splicing, structure, stability, and translation. Its dysfunction is strongly associated with the development of human malignancies. Research advances with respect to the regulatory role of RNA modifications in ovarian cancer include N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), and N7-methylguanosine (m7G). Numerous studies have demonstrated that epigenetic modifications of RNA can influence the progression and metastasis of ovarian cancer and may provide excellent targets for cancer therapy. This review highlights advances in research on RNA methylation modifications and ovarian cancer prognosis, carcinogenesis, and resistance, which could provide a theoretical foundation for designing therapeutic strategies for ovarian cancer based on RNA methylation modifications. Taylor & Francis 2023-05-16 /pmc/articles/PMC10193916/ /pubmed/37194218 http://dx.doi.org/10.1080/15476286.2023.2213915 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Review
Zhao, Shijie
Zhang, Mengxue
Zhu, Xiaolan
Xing, Jie
Zhou, Jiaming
Yin, Xinming
The potential regulatory role of RNA methylation in ovarian cancer
title The potential regulatory role of RNA methylation in ovarian cancer
title_full The potential regulatory role of RNA methylation in ovarian cancer
title_fullStr The potential regulatory role of RNA methylation in ovarian cancer
title_full_unstemmed The potential regulatory role of RNA methylation in ovarian cancer
title_short The potential regulatory role of RNA methylation in ovarian cancer
title_sort potential regulatory role of rna methylation in ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193916/
https://www.ncbi.nlm.nih.gov/pubmed/37194218
http://dx.doi.org/10.1080/15476286.2023.2213915
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